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Alcohol Dehydrogenase Polymorphism in Populations of Drosophila Melanogaster. II. Relation Between ADH Activity and Adult Mortality

Overview
Journal Biochem Genet
Specialty Molecular Biology
Date 1978 Jun 1
PMID 104710
Citations 17
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Abstract

Eight Drosophila melanogaster strains, seven homozygous for AdhF alleles and one for an Adh-null mutant, were compared for ADH activity in males and adult mortality on ethanol-supplemented food. The strains differed considerably in these qualities. A positive correlation was found between ADH activity and LD50. The relevance of this finding is discussed in relation to the differential selection acting on Adh genotypes kept on ethanol-supplemented food.

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References
1.
van Delden W, Kamping A, Van Dijk H . Selection at the alcoholdehydrogenase locus in Drosophila melanogaster. Experientia. 1975; 31(4):418-20. DOI: 10.1007/BF02026351. View

2.
Day T, Hillier P, Clarke B . The relative quantities and catalytic activities of enzymes produced by alleles at the alcohol dehydrogenase locus in Drosophila melanogaster. Biochem Genet. 1974; 11(2):155-65. DOI: 10.1007/BF00485771. View

3.
de Jong G, Scharloo W . Environmental determination of selective significance or neutrality of amylase variants in Drosophila melanogaster. Genetics. 1976; 84(1):77-94. PMC: 1213567. DOI: 10.1093/genetics/84.1.77. View

4.
Birley A, Barnes B . Genetical variation for enzyme activity in a population of Drosophila melanogaster. I. Extent of the variation for alcohol dehydrogenase activity. Heredity (Edinb). 1973; 31(3):413-6. DOI: 10.1038/hdy.1973.97. View

5.
Barnes B, Birley A . Genetical variation for enzyme activity in a population of Drosophila melanogaster. II. Aspects of the inheritance of alcohol dehydrogenase activity in Adhs/s flies. Heredity (Edinb). 1975; 35(1):115-9. DOI: 10.1038/hdy.1975.72. View