A Role for Transcriptional Repressors in Targeting the Yeast Swi/Snf Complex

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 1999 Aug 13

PMID 10445029

Citations 53

Authors

D Dimova

Z Nackerdien

S Furgeson

S Eguchi

M A Osley

Affiliations

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Abstract

Genetic and biochemical studies indicate that the evolutionarily conserved Swi/Snf complex acts at a subset of genes to help transcriptional activators function on chromatin templates. The mechanism by which this complex is targeted to specific chromosomal loci remains unknown. We show that Swi/Snf is required for expression of the yeast histone HTA1-HTB1 locus because of the role of Hir1p and Hir2p corepressors in negatively regulating transcription. Snf5p, Snf2p/Swi2p, and Swi3p, three components of the yeast Swi/Snf complex, coimmunoprecipitate with each Hir protein, and Snf5p is maximally associated with the HTA1-HTB1 promoter when the Hir-based repression system is intact and the Swi/Snf complex is functional. The data support a role for the Hir repressors in the gene-specific targeting of Swi/Snf.

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