Loss of Daxx, a Promiscuously Interacting Protein, Results in Extensive Apoptosis in Early Mouse Development

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 1999 Aug 13

PMID 10444590

Citations 88

Authors

J S Michaelson

D Bader

F Kuo

C Kozak

P Leder

Affiliations

Soon will be listed here.

Abstract

The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown. To elucidate the in vivo role of Daxx, we have generated Daxx-deficient mice. Surprisingly, rather than a hyperproliferative disorder expected from the loss of a pro-apoptotic gene, mutation of Daxx results in extensive apoptosis and embryonic lethality. These findings argue against a role for Daxx in promoting Fas-induced cell death and suggest that Daxx either directly or indirectly suppresses apoptosis in the early embryo.

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