Sublocalization of Putative Tumor Suppressor Gene Loci on Chromosome Arm 14q in Neuroblastoma

Overview

Journal Genes Chromosomes Cancer

Specialties Molecular Biology
Oncology

Date 1999 Aug 10

PMID 10441004

Citations 7

Authors

M Theobald

H Christiansen

A Schmidt

B MELEKIAN

N Wolkewitz

N M Christiansen

C Brinkschmidt

F Berthold

F Lampert

Affiliations

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Abstract

RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40-46, 1999.

Citing Articles

Intra-Tumour Genetic Heterogeneity and Prognosis in High-Risk Neuroblastoma.

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PMID: 34680323 PMC: 8534138. DOI: 10.3390/cancers13205173.

KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.

Klinke O, Mizani T, Baldwin G, Bancel B, Devouassoux-Shisheboran M, Scoazec J PLoS One. 2015; 10(6):e0130149.

PMID: 26102504 PMC: 4477893. DOI: 10.1371/journal.pone.0130149.

Loss of 14q chromosome in oligodendroglial and astrocytic tumors.

Dichamp C, Taillibert S, Aguirre-Cruz L, Lejeune J, Marie Y, Kujas M J Neurooncol. 2004; 67(3):281-5.

PMID: 15164983 DOI: 10.1023/b:neon.0000024218.68120.8d.

Current status of human chromosome 14.

Kamnasaran D, Cox D J Med Genet. 2002; 39(2):81-90.

PMID: 11836355 PMC: 1735028. DOI: 10.1136/jmg.39.2.81.

Neuroblastoma tumour genetics: clinical and biological aspects.

Bown N J Clin Pathol. 2001; 54(12):897-910.

PMID: 11729208 PMC: 1731335. DOI: 10.1136/jcp.54.12.897.