Vasopressin-like Effects of Psychotropic Drugs in Amphibian Epithelia

Overview

Journal J Membr Biol

Date 1978 Jan 1

PMID 104041

Citations 6

Authors

A Grosso

R C de Sousa

Affiliations

Soon will be listed here.

Abstract

Amphibian epithelia have been used as models for studying the effects of psychotropic drugs on membrane transport. Several of these agents added to the internal or to the external media, at concentrations greater than 10(-3) M, had inhibitory, "ouabain-like" effects on Na transport. In contrast, stimulatory, "vasopressin-like" effects were seen at lower concentrations. The stimulation was additive to that of oxytocin if the drug was present in the external solution but nonadditive if in the internal solution. On water transport, harmala alkaloids had a vasopressinomimetic action in toad skin, while inhibition was seen with Li and amitriptyline. To account for these multiple effects, it is hypothesized that psychotropic drugs act on the following cell targets: the Na pump, the cyclic nucleotide system, microtubules, and membrane calcium sites at the outer barrier of the epithelium. Direct, biochemical evidence is needed to substantiate this hypothesis.

Citing Articles

Cellular and membrane events involved in the K-induced increase in water permeability of toad skin.

Grosso A, Brown D, de Sousa R Pflugers Arch. 1982; 395(2):145-51.

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Quercetin enhances water transport in toad bladder.

Grosso A, de Sousa R Experientia. 1981; 37(7):742-4.

PMID: 6268437 DOI: 10.1007/BF01967956.

Phenothiazines increase active sodium transport across the isolated toad skin.

Berman D, Soria M, Coviello A Pflugers Arch. 1986; 407(3):327-32.

PMID: 3093973 DOI: 10.1007/BF00585310.

Na transport stimulation by novobiocin: transepithelial parameters and evaluation of ENa.

Rick R, Dorge A, Sesselmann E Pflugers Arch. 1988; 411(3):243-51.

PMID: 2454448 DOI: 10.1007/BF00585110.

Inhibitory and stimulatory effects of amiloride analogues on sodium transport in frog skin.

Li J, de Sousa R J Membr Biol. 1979; 46(2):155-69.

PMID: 448731 DOI: 10.1007/BF01961378.

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