The 3' Non-coding Region of the Drosophila Melanogaster HeT-A Telomeric Retrotransposon Contains Sequences with Propensity to Form G-quadruplex DNA
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HeT-A elements are non-long terminal repeat retrotransposons added onto the Drosophila chromosome ends. We have investigated the formation in vitro of higher order structures by oligonucleotides derived from the 3' non-coding region of HeT-A elements and found that they are capable of forming G-quadruplex DNA. These results suggest that the 3' repeat region of HeT-A may structurally behave as the telomeric repeats common to a majority of eukaryotes. The presence of structural motifs shared by telomeres and centromeres and the implications of these findings for chromosome evolution are discussed.
Multiple Roles of dXNP and dADD1- Orthologs of ATRX Chromatin Remodeler.
Melnikova L, Golovnin A Int J Mol Sci. 2023; 24(22).
PMID: 38003676 PMC: 10671109. DOI: 10.3390/ijms242216486.
Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species.
Jedlicka P, Tokan V, Kejnovska I, Hobza R, Kejnovsky E Mob DNA. 2023; 14(1):3.
PMID: 37038191 PMC: 10088271. DOI: 10.1186/s13100-023-00291-9.
G-Quadruplexes at Telomeres: Friend or Foe?.
Bryan T Molecules. 2020; 25(16).
PMID: 32823549 PMC: 7464828. DOI: 10.3390/molecules25163686.
Transposable elements and G-quadruplexes.
Kejnovsky E, Tokan V, Lexa M Chromosome Res. 2015; 23(3):615-23.
PMID: 26403244 DOI: 10.1007/s10577-015-9491-7.
Guanine quadruplex structures localize to heterochromatin.
Hoffmann R, Moshkin Y, Mouton S, Grzeschik N, Kalicharan R, Kuipers J Nucleic Acids Res. 2015; 44(1):152-63.
PMID: 26384414 PMC: 4705689. DOI: 10.1093/nar/gkv900.