Modulating Nuclear Receptor Function: May the Phos Be with You

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1999 Jun 22

PMID 10377165

Citations 35

Authors

D Shao

M A Lazar

Affiliations

Soon will be listed here.

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References

Glineur C, Zenke M, Beug H, Ghysdael J . Phosphorylation of the v-erbA protein is required for its function as an oncogene. Genes Dev. 1990; 4(10):1663-76. DOI: 10.1101/gad.4.10.1663. View

Solomon C, White J, Kremer R . Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. J Clin Invest. 1999; 103(12):1729-35. PMC: 408392. DOI: 10.1172/JCI6871. View

Bhat M, Ashizawa K, Cheng S . Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor. Proc Natl Acad Sci U S A. 1994; 91(17):7927-31. PMC: 44517. DOI: 10.1073/pnas.91.17.7927. View

Zhang Y, Beck C, Poletti A, Edwards D, Weigel N . Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II. J Biol Chem. 1994; 269(49):31034-40. View

Katz D, Reginato M, Lazar M . Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation. Mol Cell Biol. 1995; 15(5):2341-8. PMC: 230462. DOI: 10.1128/MCB.15.5.2341. View

Rochette-Egly C, Oulad-Abdelghani M, Staub A, Pfister V, Scheuer I, Chambon P . Phosphorylation of the retinoic acid receptor-alpha by protein kinase A. Mol Endocrinol. 1995; 9(7):860-71. DOI: 10.1210/mend.9.7.7476969. View

Mangelsdorf D, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K . The nuclear receptor superfamily: the second decade. Cell. 1995; 83(6):835-9. PMC: 6159888. DOI: 10.1016/0092-8674(95)90199-x. View

Dowhan D, Muscat G . Characterization of the AB (AF-1) region in the muscle-specific retinoid X receptor-gamma: evidence that the AF-1 region functions in a cell-specific manner. Nucleic Acids Res. 1996; 24(2):264-71. PMC: 145623. DOI: 10.1093/nar/24.2.264. View

Auricchio F, Migliaccio A, Castoria G, Di Domenico M, Bilancio A, Rotondi A . Protein tyrosine phosphorylation and estradiol action. Ann N Y Acad Sci. 1996; 784:149-72. DOI: 10.1111/j.1749-6632.1996.tb16234.x. View

10.

Nazareth L, Weigel N . Activation of the human androgen receptor through a protein kinase A signaling pathway. J Biol Chem. 1996; 271(33):19900-7. DOI: 10.1074/jbc.271.33.19900. View

11.

Shalev A, Yen P, Wahli W, Burger A, Chin W, Meier C . The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology. 1996; 137(10):4499-502. DOI: 10.1210/endo.137.10.8828512. View

12.

Ting Y, Bhat M, Wong R, Cheng S . Tissue-specific stabilization of the thyroid hormone beta1 nuclear receptor by phosphorylation. J Biol Chem. 1997; 272(7):4129-34. DOI: 10.1074/jbc.272.7.4129. View

13.

Adams M, Reginato M, Shao D, Lazar M, Chatterjee V . Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem. 1997; 272(8):5128-32. DOI: 10.1074/jbc.272.8.5128. View

14.

Jiang G, Nepomuceno L, Yang Q, Sladek F . Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4. Arch Biochem Biophys. 1997; 340(1):1-9. DOI: 10.1006/abbi.1997.9914. View

15.

Zhang Y, Beck C, Poletti A, Clement 4th J, PRENDERGAST P, Yip T . Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo. Mol Endocrinol. 1997; 11(6):823-32. DOI: 10.1210/mend.11.6.0006. View

16.

Krstic M, Rogatsky I, Yamamoto K, Garabedian M . Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol Cell Biol. 1997; 17(7):3947-54. PMC: 232247. DOI: 10.1128/MCB.17.7.3947. View

17.

Taneja R, Rochette-Egly C, Plassat J, Penna L, Gaub M, Chambon P . Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment. EMBO J. 1997; 16(21):6452-65. PMC: 1170251. DOI: 10.1093/emboj/16.21.6452. View

18.

Radhakrishnan I, Parker D, Dyson H, Montminy M, Wright P . Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997; 91(6):741-52. DOI: 10.1016/s0092-8674(00)80463-8. View

19.

Privalsky M . Phosphorylation of thyroid hormone receptors by protein kinase A regulates DNA recognition by specific inhibition of receptor monomer binding. J Biol Chem. 1998; 273(18):10926-32. DOI: 10.1074/jbc.273.18.10926. View

20.

Rogatsky I, Waase C, Garabedian M . Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3.... J Biol Chem. 1998; 273(23):14315-21. DOI: 10.1074/jbc.273.23.14315. View