Comparison of Xylitol and Glucose Metabolism in Nonhepatic Rat Tissues

Overview

Journal Z Ernahrungswiss

Specialty Nutritional Sciences

Date 1976 Dec 1

PMID 1020371

Citations 3

Authors

K H Quadflieg

K Brand

Affiliations

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Abstract

Capability and extent of xylitol metabolism in vitro was studied in a variety of non-hepatic tissues of rats, using enzymatic and isotopic methods. Only kidney was found to be able to utilize xylitol at a significant rate while in all other organs tested - lung, brain, heart muscle, skeletal muscle and adipose tissue - no uptake of xylitol was detectable using two independent methods. In accordance with these results the incorporation of radioactivity from [U-14C]-xylitol as substrate into the products CO2 and lactate was found to be very small in all organs with the exception of kidney and when compared to that from [U-14C]-glucose it was less than 5%. From these results it is concluded that besides liver only kidney can utilize xylitol to a significant extent while for the other tissues studied xylitol is not a suitable substrate.

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References

Wang M, Meng H . Xylitol metabolism in extrahepatic tissues. Z Ernahrungswiss Suppl. 1971; 11:8-16. View

Lang K . [Xylitol, metabolism and clinical use]. Klin Wochenschr. 1971; 49(5):233-45. DOI: 10.1007/BF01485423. View

Katz J, Brand K, Golden S, Rubinstein D . Lactate and pyruvate metabolism and reducing equivalent transfer in Ehrlich ascites tumor. Cancer Res. 1974; 34(4):872-7. View

Quadflieg K, Brand K . [Xylitol metabolism in human erythrocytes]. Z Ernahrungswiss. 1975; 14(4):268-71. DOI: 10.1007/BF02025864. View

Opitz K . [On the action of sugars, sugar alcohols and related substances on the fat mobilization]. Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966; 255(2):192-9. View

Woods H, KREBS H . Xylitol metabolism in the isolated perfused rat liver. Biochem J. 1973; 134(2):437-43. PMC: 1177829. DOI: 10.1042/bj1340437. View

MADER H, Reinauer H . [Utilization of xylitol in the isolation-perfused myocardium of the rat]. Z Ernahrungswiss. 1976; 15(1):54-8. DOI: 10.1007/BF02283137. View

Asakura T, Adachi K, Minagami S, Yoshikawa H . Non-glycolytic sugar metabolism in human erythrocytes. I. Xylitol metabolism. J Biochem. 1967; 62(2):184-93. DOI: 10.1093/oxfordjournals.jbchem.a128647. View

Thomas D, EDWARDS J, Gilligan J, Lawrence J, Edwards R . Complications following intravenous administration of solutions containing xylitol. Med J Aust. 1972; 1(24):1238-46. DOI: 10.5694/j.1326-5377.1972.tb116530.x. View

10.

Stein H, Cohen J . The measurement by a microtitration technique of carbon dioxide production in rat brain slices. Studis with glucose, fructose, and xylitol. Anal Biochem. 1976; 71(2):444-51. DOI: 10.1016/s0003-2697(76)80010-3. View

11.

Muller F, STRACK E, KUHFAHL E, Dettmer D . [The metabolism of xylitol in normal and alloxan diabetic rabbits]. Z Gesamte Exp Med Einschl Exp Chir. 1967; 142(4):338-50. View

12.

BAESSLER K, Prellwitz W, UNBEHAUN V, Lang K . [Xylitol metabolism in man. On the problem of the suitability of xylitol as a sugar substitute in diabetics]. Klin Wochenschr. 1962; 40:791-3. DOI: 10.1007/BF01481253. View

13.

Folch J, Lees M, SLOANE STANLEY G . A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957; 226(1):497-509. View

14.

Opitz K, Lutz M . [Xylitol and blood-brain barrier]. Z Ernahrungswiss Suppl. 1971; 11:39-43. View

15.

ROGNSTAD R, Katz J . The mechanism of the non-oxidative segment of the pentose cycle in the liver. Biochem Biophys Res Commun. 1974; 61(2):774-80. DOI: 10.1016/0006-291x(74)91024-9. View

16.

Mehnert H, Summa J, Foerster H . [STUDIES ON XYLITOL METABOLISM IN HEALTHY SUBJECTS AND PATIENTS WITH LIVER DISEASE AND DIABETES]. Klin Wochenschr. 1964; 42:382-7. DOI: 10.1007/BF01488634. View

17.

Rodbell M . METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem. 1964; 239:375-80. View

18.

Ashcroft S, Weerasinghe L, BASSETT J, Randle P . The pentose cycle and insulin release in mouse pancreatic islets. Biochem J. 1972; 126(3):525-32. PMC: 1178408. DOI: 10.1042/bj1260525. View

19.

Hollmann S, Laumann G . [On the occurrence and activity of xylitol:NADO-oxidoreductase (L-xylulose-forming) in vertebrates]. Hoppe Seylers Z Physiol Chem. 1967; 348(8):1073-6. View