Alpha 2.0
Login Register
» Articles » PMID: 10103189

Molecular Characterization of an Antibiotic Resistance Gene Cluster of Salmonella Typhimurium DT104

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1999 Apr 2
PMID 10103189
Citations 103
Authors
C E Briggs
P M Fratamico
Affiliations
Soon will be listed here.
Abstract

Salmonella typhimurium phage type DT104 has become an important emerging pathogen. Isolates of this phage type often possess resistance to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline (ACSSuT resistance). The mechanism by which DT104 has accumulated resistance genes is of interest, since these genes interfere with treatment of DT104 infections and might be horizontally transferred to other bacteria, even to unrelated organisms. Previously, several laboratories have shown that the antibiotic resistance genes of DT104 are chromosomally encoded and involve integrons. The antibiotic resistance genes conferring the ACSSuT-resistant phenotype have been cloned and sequenced. These genes are grouped within two district integrons and intervening plasmid-derived sequences. This sequence is potentially useful for detection of multiresistant DT104.

Citing Articles

Trends in horizontal gene transfer research in antimicrobial resistance: a bibliometric analysis.

Yan J, Doublet B, Wiedemann A Front Microbiol. 2024; 15:1439664.

PMID: 39328914 PMC: 11424403. DOI: 10.3389/fmicb.2024.1439664.

Maribacter halichondriae sp. nov., isolated from the marine sponge Halichondria panicea, displays features of a sponge-associated life style.

Steiner L, Wiese J, Rahn T, Borchert E, Slaby B, Hentschel U Antonie Van Leeuwenhoek. 2024; 117(1):56.

PMID: 38489089 PMC: 10942906. DOI: 10.1007/s10482-024-01950-4.

Salmonella serovars trend in poultry Malaysia from 2011 to 2020.

Ibrahim M, Jusoh M, Rose F, Azami M, Roslee R Vet Res Commun. 2024; 48(3):1791-1802.

PMID: 38238509 DOI: 10.1007/s11259-024-10303-5.

Antimicrobial resistance and virulence genes of invasive from children with bacteremia in north-central Nigeria.

Uzairue L, Shittu O, Ojo O, Obuotor T, Olanipekun G, Ajose T SAGE Open Med. 2023; 11:20503121231175322.

PMID: 37223673 PMC: 10201152. DOI: 10.1177/20503121231175322.

Antibiotic-Resistant Bacteria in Aquaculture and Climate Change: A Challenge for Health in the Mediterranean Area.

Pepi M, Focardi S Int J Environ Res Public Health. 2021; 18(11).

PMID: 34073520 PMC: 8198758. DOI: 10.3390/ijerph18115723.

References
1.
Sandvang D, Aarestrup F, Jensen L . Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104. FEMS Microbiol Lett. 1998; 160(1):37-41. DOI: 10.1111/j.1574-6968.1998.tb12887.x. View
2.
Williams R, Heymann D . Containment of antibiotic resistance. Science. 1998; 279(5354):1153-4. DOI: 10.1126/science.279.5354.1153. View
3.
Ferber D . New hunt for the roots of resistance. Science. 1998; 280(5360):27. DOI: 10.1126/science.280.5360.27. View
4.
Glynn M, Bopp C, DeWitt W, Dabney P, Mokhtar M, Angulo F . Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States. N Engl J Med. 1998; 338(19):1333-8. DOI: 10.1056/NEJM199805073381901. View
5.
Southern E . Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975; 98(3):503-17. DOI: 10.1016/s0022-2836(75)80083-0. View