Dealing with Energy Demand: the AMP-activated Protein Kinase

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1999 Mar 24

PMID 10087918

Citations 159

Authors

B E Kemp

K I Mitchelhill

D Stapleton

B J Michell

Z P Chen

L A Witters

Affiliations

Soon will be listed here.

Abstract

The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.

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