Genetic Conflicts in Genomic Imprinting

Overview

Journal Proc Biol Sci

Specialty Biology

Date 1999 Mar 13

PMID 10075542

Citations 20

Authors

A Burt

R Trivers

Affiliations

Soon will be listed here.

Abstract

The expression pattern of genes in mammals and plants can depend upon the parent from which the gene was inherited, evidence for a mechanism of parent-specific genomic imprinting. Kinship considerations are likely to be important in the natural selection of many such genes, because coefficients of relatedness will usually differ between maternally and paternally derived genes. Three classes of gene are likely to be involved in genomic imprinting: the imprinted genes themselves, trans-acting genes in the parents, which affect the application of the imprint, and trnas-acting genes in the offspring, which recognize and affect the expression of the imprint. We show that coefficients of relatedness will typically differ among these three classes, thus engendering conflicts of interest between Imprinter genes, imprinted genes, and imprint-recognition genes, with probable consequences for the evolution of the imprinting machinery.

Citing Articles

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References

Hamilton W . The genetical evolution of social behaviour. II. J Theor Biol. 1964; 7(1):17-52. DOI: 10.1016/0022-5193(64)90039-6. View

Hamilton W . The genetical evolution of social behaviour. I. J Theor Biol. 1964; 7(1):1-16. DOI: 10.1016/0022-5193(64)90038-4. View

Hamilton W . The moulding of senescence by natural selection. J Theor Biol. 1966; 12(1):12-45. DOI: 10.1016/0022-5193(66)90184-6. View

Charlesworth B, Charnov E . Kin selection in age-structured populations. J Theor Biol. 1981; 88(1):103-19. DOI: 10.1016/0022-5193(81)90330-1. View

Moore T, Haig D . Genomic imprinting in mammalian development: a parental tug-of-war. Trends Genet. 1991; 7(2):45-9. DOI: 10.1016/0168-9525(91)90230-N. View

Norris D, Patel D, Kay G, Penny G, Brockdorff N, Sheardown S . Evidence that random and imprinted Xist expression is controlled by preemptive methylation. Cell. 1994; 77(1):41-51. DOI: 10.1016/0092-8674(94)90233-x. View

Efstratiadis A . Parental imprinting of autosomal mammalian genes. Curr Opin Genet Dev. 1994; 4(2):265-80. DOI: 10.1016/s0959-437x(05)80054-1. View

Vu T, Hoffman A . Promoter-specific imprinting of the human insulin-like growth factor-II gene. Nature. 1994; 371(6499):714-7. DOI: 10.1038/371714a0. View

Chaillet J, Bader D, Leder P . Regulation of genomic imprinting by gametic and embryonic processes. Genes Dev. 1995; 9(10):1177-87. DOI: 10.1101/gad.9.10.1177. View

10.

Ariel M, Robinson E, McCarrey J, Cedar H . Gamete-specific methylation correlates with imprinting of the murine Xist gene. Nat Genet. 1995; 9(3):312-5. DOI: 10.1038/ng0395-312. View

11.

Zuccotti M, Monk M . Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X-inactivation. Nat Genet. 1995; 9(3):316-20. DOI: 10.1038/ng0395-316. View

12.

Buiting K, Saitoh S, Gross S, Dittrich B, Schwartz S, Nicholls R . Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nat Genet. 1995; 9(4):395-400. DOI: 10.1038/ng0495-395. View

13.

Barlow D . Gametic imprinting in mammals. Science. 1995; 270(5242):1610-3. DOI: 10.1126/science.270.5242.1610. View

14.

Razin A, Shemer R . DNA methylation in early development. Hum Mol Genet. 1995; 4 Spec No:1751-5. DOI: 10.1093/hmg/4.suppl_1.1751. View

15.

Shemer R, Birger Y, Dean W, Reik W, Riggs A, Razin A . Dynamic methylation adjustment and counting as part of imprinting mechanisms. Proc Natl Acad Sci U S A. 1996; 93(13):6371-6. PMC: 39029. DOI: 10.1073/pnas.93.13.6371. View

16.

Dittrich B, Buiting K, Korn B, Rickard S, Buxton J, Saitoh S . Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene. Nat Genet. 1996; 14(2):163-70. DOI: 10.1038/ng1096-163. View

17.

Mochizuki A, Takeda Y, Iwasa Y . The evolution of genomic imprinting. Genetics. 1996; 144(3):1283-95. PMC: 1207619. DOI: 10.1093/genetics/144.3.1283. View

18.

Spencer H, WILLIAMS M . The evolution of genomic imprinting: two modifier-locus models. Theor Popul Biol. 1997; 51(1):23-35. DOI: 10.1006/tpbi.1997.1293. View

19.

Reik W, Maher E . Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome. Trends Genet. 1997; 13(8):330-4. DOI: 10.1016/s0168-9525(97)01200-6. View

20.

Moore T, Reik W . Genetic conflict in early development: parental imprinting in normal and abnormal growth. Rev Reprod. 1996; 1(2):73-7. DOI: 10.1530/ror.0.0010073. View