The Regulation of Neurotransmitter Secretion by Protein Kinase C

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 1999 Mar 5

PMID 10065877

Citations 22

Authors

P F Vaughan

J H Walker

C Peers

Affiliations

Soon will be listed here.

Abstract

The effect of protein kinase C (PKC) on the release of neurotransmitters from a number preparations, including sympathetic nerve endings, brain slices, synaptosomes, and neuronally derived cell lines, is considered. A comparison is drawn between effects of activation of PKC on neurotransmitter release from small synaptic vesicles and large dense-cored vesicles. The enhancement of neurotransmitter release is discussed in relation to the effect of PKC on: 1. Rearrangement of the F-actin-based cytoskeleton, including the possible role of MARCKS in this process, to allow access of large dense-cored vesicles to release sites on the plasma membrane. 2. Phosphorylation of key components in the SNAP/SNARE complex associated with the docking and fusion of vesicles at site of secretion. 3. Ion channel activity, particularly Ca2+ channels.

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