Fosfomycin Alters Lipopolysaccharide-induced Inflammatory Cytokine Production in Mice

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1999 Feb 27

PMID 10049293

Citations 10

Authors

T Matsumoto

K Tateda

S Miyazaki

N Furuya

A Ohno

Y Ishii

Y Hirakata

K Yamaguchi

Affiliations

Soon will be listed here.

Abstract

To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1 beta, indicating that FOF alters inflammatory cytokine production after LPS stimulation.

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