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Comparison of Efficacies of Oral Levofloxacin and Oral Ciprofloxacin in a Rabbit Model of a Staphylococcal Abscess

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1999 Feb 27
PMID 10049285
Citations 7
Authors
J Fernandez
J F Barrett
L Licata
D Amaratunga
M Frosco
Affiliations
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Abstract

Oral levofloxacin was compared to oral ciprofloxacin in a Staphylococcus aureus subcutaneous abscess model in rabbits. Rabbits were surgically prepared with subcutaneous wiffle balls (43 mm in diameter) and allowed to recover for 4 to 6 weeks. Rabbits were infected by direct injection into the capsule with S. aureus ATCC 29213 (5 x 10(5) CFU) and were allowed to remain infected for 8 days before the initiation of anti-infective treatment. Efficacy was determined by assessing the bacterial load within the capsule over a 10-day treatment period. In single-dose pharmacokinetic studies in infected rabbits, similar area under the concentration-time curve/MIC ratios were obtained in the plasma and abscess fluid for levofloxacin at 45 mg/kg of body weight and ciprofloxacin at 200 mg/kg of body weight. Similar efficacies were seen with levofloxacin at 45 mg/kg/day and ciprofloxacin 400 mg/kg/day by day 10. In this model, levofloxacin was significantly more efficacious than ciprofloxacin (P < 0.01).

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References
1.
Gerding D, Hall W, Schierl E, MANION R . Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits. Antimicrob Agents Chemother. 1976; 10(6):902-11. PMC: 429863. DOI: 10.1128/AAC.10.6.902. View
2.
Tally F . Factors affecting antimicrobial agents in an anaerobic abscess. J Antimicrob Chemother. 1978; 4(4):299-302. DOI: 10.1093/jac/4.4.299. View
3.
Bamberger D, Peterson L, Gerding D, Moody J, Fasching C . Ciprofloxacin, azlocillin, ceftizoxime and amikacin alone and in combination against gram-negative bacilli in an infected chamber model. J Antimicrob Chemother. 1986; 18(1):51-63. DOI: 10.1093/jac/18.1.51. View
4.
Matsui H, Okuda T . Penetration of cefpiramide and cefazolin into peritoneal capsular fluid in rabbits. Antimicrob Agents Chemother. 1988; 32(1):33-6. PMC: 172093. DOI: 10.1128/AAC.32.1.33. View
5.
Chien S, Rogge M, Gisclon L, Curtin C, Wong F, Natarajan J . Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses. Antimicrob Agents Chemother. 1997; 41(10):2256-60. PMC: 164102. DOI: 10.1128/AAC.41.10.2256. View