Investigational New Drugs
Overview
Investigational New Drugs is a peer-reviewed scientific journal that focuses on the development and evaluation of novel therapeutic agents for the treatment of various diseases. It publishes cutting-edge research articles, reviews, and clinical trials, providing valuable insights into the discovery and development of innovative drugs. The journal serves as a platform for researchers, clinicians, and pharmaceutical professionals to share their findings and contribute to the advancement of drug discovery and development.
Details
Details
Abbr.
Invest New Drugs
Publisher
Springer
Start
1983
End
Continuing
Frequency
Quarterly
p-ISSN
0167-6997
e-ISSN
1573-0646
Country
United States
Language
English
Specialty
Oncology
Metrics
Metrics
h-index / Ranks: 3275
97
SJR / Ranks: 3293
1086
CiteScore / Ranks: 3060
6.80
JIF / Ranks: 2884
3.4
Recent Articles
11.
Oliveira L, Oliveira-Silva J, Almeida-Souza H, Martins M, Chiminazo C, Fonseca R, et al.
Invest New Drugs
. 2025 Feb;
PMID: 39954199
Glioblastoma multiforme (GBM) accounts for 70% of all primary malignancies of the central nervous system. Current treatment strategies involve surgery followed by chemotherapy with temozolomide (TMZ); however, the median survival...
12.
Wang X, Bai Z, Deng W, Wang X
Invest New Drugs
. 2025 Feb;
PMID: 39945972
Fruquintinib has been recommended for treating refractory metastatic colorectal cancer. This single-arm, phase II study explored for the first time whether fruquintinib combined with capecitabine could be used as a...
13.
Yang L, Feng Y, Liu X, Zhang Q, Liu Y, Zhang X, et al.
Invest New Drugs
. 2025 Feb;
PMID: 39934438
Dynein cytoplasmic 2 heavy chain 1 (DYNC2H1) is reported to play a potential role in cancer immunotherapy. However, the association between DYNC2H1 mutation and the clinical benefit of immunotherapy in...
14.
Zou L, Rao X, Zhao X
Invest New Drugs
. 2025 Feb;
PMID: 39907964
Pembrolizumab has shown links to autoimmune encephalitis (AE), yet the exact clinical characteristics remain unclear. This study examines the clinical features of pembrolizumab-induced AE to enhance diagnostic accuracy and therapeutic...
15.
Ma L, Zhang Y, Fang Y, Hao C, Fan Q, Jiang D, et al.
Invest New Drugs
. 2025 Jan;
PMID: 39883265
Background: Immune checkpoint inhibitors (ICIs) combined with anti-vascular endothelial growth factor (VEGF) have been the standard first-line treatment of hepatocellular carcinoma (HCC). However, the efficacy of this combination in post-line...
16.
Tang M, Crown J, Duffy M
Invest New Drugs
. 2025 Jan;
43(1):167-179.
PMID: 39875774
Background: Since MYC is one of the most frequently altered driver genes involved in cancer formation, it is a potential target for new anti-cancer therapies. Historically, however, MYC has proved...
17.
Ma S, Xu Y, Liu M, Wu S, Zhang Y, Xia H, et al.
Invest New Drugs
. 2025 Jan;
43(1):157-166.
PMID: 39869284
Due to the emergence of drug resistance, androgen receptor (AR)-targeted drugs still pose great challenges in the treatment of prostate cancer, and it is urgent to explore an innovative therapeutic...
18.
Kaneda H, Daga H, Okada A, Nakatani Y, Tani Y, Oka T, et al.
Invest New Drugs
. 2025 Jan;
43(1):147-156.
PMID: 39847172
Background: The RELAY-Brain trial examined the clinical utility and survival impacts of ramucirumab (RAM) combined with epidermal growth factor receptor (EGFR)-TKI in patients with EGFR-mutated non-small-cell lung cancer (NSCLC) with...
19.
Banchi M, Cox M, Bandini A, Orlandi P, Tacchi C, Stefanelli F, et al.
Invest New Drugs
. 2025 Jan;
43(1):135-146.
PMID: 39821757
Cutaneous T-cell lymphomas (CTCLs) are a rare and heterogeneous subset of skin-localized, non-Hodgkin lymphomas. Our aim was to evaluate the in vitro antitumor activity of the multi-kinase inhibitor linifanib, either...
20.
Li X, Wu Y, Han T, Ding R, Kong R, Chen S, et al.
Invest New Drugs
. 2025 Jan;
43(1):126-134.
PMID: 39800815
Gliomas are a heterogeneous type of central nervous system tumor. The etiology of glioma formation remains elusive, with approximately 5% of gliomas being familial, underscoring the significance of understanding genetic...