Zinaida S Vexler
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Explore the profile of Zinaida S Vexler including associated specialties, affiliations and a list of published articles.
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59
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2767
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Recent Articles
1.
Vecchiarelli H, Bisht K, Sharma K, Novak S, Traetta M, Garcia-Segura M, et al.
bioRxiv
. 2024 Oct;
PMID: 39463930
This study examined dark microglia-a state linked to central nervous system pathology and neurodegeneration-during postnatal development in the mouse ventral hippocampus, finding that dark microglia interact with blood vessels and...
2.
Chumak T, Jullienne A, Ek C, Ardalan M, Svedin P, Quan R, et al.
J Neuroinflammation
. 2024 Aug;
21(1):199.
PMID: 39128994
Infection during the perinatal period can adversely affect brain development, predispose infants to ischemic stroke and have lifelong consequences. We previously demonstrated that diet enriched in n-3 polyunsaturated fatty acids...
3.
Maternal n-3 enriched diet reprograms neurovascular transcriptome and blunts inflammation in neonate
Chumak T, Jullienne A, Ek C, Ardalan M, Svedin P, Quan R, et al.
bioRxiv
. 2024 Feb;
PMID: 38328227
Infection during perinatal period can adversely affect brain development, predispose infants to ischemic stroke and have lifelong consequences. We previously demonstrated that diet enriched in n-3 polyunsaturated fatty acids (PUFA)...
4.
Mallard C, Ferriero D, Vexler Z
Stroke
. 2024 Jan;
55(2):506-518.
PMID: 38252757
Emerging clinical and preclinical data have demonstrated that the pathophysiology of arterial ischemic stroke in the adult, neonates, and children share similar mechanisms that regulate brain damage but also have...
5.
Fukuzaki Y, Faustino J, Lecuyer M, Rayasam A, Vexler Z
iScience
. 2023 Apr;
26(4):106340.
PMID: 37009213
Arterial ischemic stroke is common in neonates-1 per 2,300-5,000 births-and therapeutic targets remain insufficiently defined. Sphingosine-1-phosphate receptor 2 (S1PR2), a major regulator of the CNS and immune systems, is injurious...
6.
Gadagkar S, Lalancette-Hebert M, Thammisetty S, Vexler Z, Kriz J
Sci Rep
. 2023 Feb;
13(1):2304.
PMID: 36759676
Innate immune response in neonatal brain is associated with a robust microglial activation and induction of Toll-like Receptors (TLRs). To date, the role of the scavenger receptor CD36 in TLRs...
7.
Di Martino E, Rayasam A, Vexler Z
Transl Stroke Res
. 2023 Jan;
15(1):69-86.
PMID: 36705821
Injuries in the developing brain cause significant long-term neurological deficits. Emerging clinical and preclinical data have demonstrated that the pathophysiology of neonatal and childhood stroke share similar mechanisms that regulate...
8.
Rayasam A, Mottahedin A, Faustino J, Mallard C, Vexler Z
J Neuroinflammation
. 2022 Feb;
19(1):47.
PMID: 35148760
Background: Ischemic stroke induces the activation and recruitment of peripheral leukocytes to the injured brain. These cells can infiltrate the brain through multiple routes, either by penetrating blood-brain barrier or...
9.
Chumak T, Lecuyer M, Nilsson A, Faustino J, Ardalan M, Svedin P, et al.
Transl Stroke Res
. 2021 Oct;
13(3):449-461.
PMID: 34674145
The fetus is strongly dependent on nutrients from the mother, including polyunsaturated fatty acids (PUFA). In adult animals, n-3 PUFA ameliorates stroke-mediated brain injury, but the modulatory effects of different...
10.
Rayasam A, Jullienne A, Chumak T, Faustino J, Szu J, Hamer M, et al.
J Cereb Blood Flow Metab
. 2021 Jul;
41(12):3171-3186.
PMID: 34293939
Stroke is among the top ten causes of death in children but has received disproportionally little attention. Cerebral arteriopathies account for up to 80% of childhood arterial ischemic stroke (CAIS)...