Zike Zhang
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Explore the profile of Zike Zhang including associated specialties, affiliations and a list of published articles.
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26
Citations
556
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Recent Articles
1.
Ping X, Li Q, Ding M, Yu Z, Yi Q, Li Y, et al.
J Mol Cell Cardiol
. 2025 Feb;
201:95-104.
PMID: 39954938
Overconsumption of fructose has been linked to the development of systemic metabolic and cardiac diseases, yet few studies have focused on the link between cardiac fructose metabolism and the development...
2.
Zhang Z, Wang F, Min Q, Jin Y, Situ G
Opt Lett
. 2024 Nov;
49(21):6129-6132.
PMID: 39485428
Fourier phase retrieval (FPR) aims to reconstruct an object image from the magnitude of its Fourier transform. Despite its widespread utility in various fields of engineering and science, the inherent...
3.
Zhang Z, Fang Q, Xie T, Gong X
Structure
. 2024 Jul;
32(9):1419-1428.e4.
PMID: 38964337
Ceramide synthases (CerSs) play crucial roles in sphingolipid metabolism and have emerged as promising drug targets for metabolic diseases, cancers, and antifungal therapy. However, the therapeutic targeting of CerSs has...
4.
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, et al.
Cell Rep
. 2024 Jan;
43(2):113717.
PMID: 38285738
The homeostatic regulation of serine palmitoyltransferase (SPT) activity in yeast involves N-terminal phosphorylation of Orm proteins, while higher eukaryotes lack these phosphorylation sites. Although recent studies have indicated a conserved...
5.
Xie T, Fang Q, Zhang Z, Wang Y, Dong F, Gong X
EMBO J
. 2023 Nov;
42(24):e114889.
PMID: 37953642
Ceramide synthases (CerS) catalyze ceramide formation via N-acylation of a sphingoid base with a fatty acyl-CoA and are attractive drug targets for treating numerous metabolic diseases and cancers. Here, we...
6.
Wu L, Vaccarella S, Feng C, Dal Maso L, Chen Y, Liu W, et al.
Eur Thyroid J
. 2023 Oct;
12(6).
PMID: 37855414
Background: Incidence rates of papillary thyroid cancer (PTC) have increased rapidly, with incidentally detected cancers contributing a large proportion. We aimed to explore the impact of incidental detection on thyroid...
7.
Xie T, Liu P, Wu X, Dong F, Zhang Z, Yue J, et al.
Nat Commun
. 2023 Jun;
14(1):3475.
PMID: 37308477
The ORM/ORMDL family proteins function as regulatory subunits of the serine palmitoyltransferase (SPT) complex, which is the initiating and rate-limiting enzyme in sphingolipid biosynthesis. This complex is tightly regulated by...
8.
Liu P, Xie T, Wu X, Han G, Gupta S, Zhang Z, et al.
Sci Adv
. 2023 Mar;
9(13):eadg0728.
PMID: 36989369
The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels....
9.
Xie X, Zhan X, Zhang Z, Liu C
Chaos
. 2023 Feb;
33(1):013104.
PMID: 36725627
Hypergraphs that can depict interactions beyond pairwise edges have emerged as an appropriate representation for modeling polyadic relations in complex systems. With the recent surge of interest in researching hypergraphs,...
10.
Xie T, Zhang Z, Yue J, Fang Q, Gong X
Sci Adv
. 2022 Apr;
8(14):eabn3727.
PMID: 35394827
The adenosine 5'-triphosphate (ATP)-binding cassette (ABC) transporter ABCA3 plays a critical role in pulmonary surfactant biogenesis. Mutations in human ABCA3 have been recognized as the most frequent causes of inherited...