Zichong Li
Overview
Explore the profile of Zichong Li including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
465
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0
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Recent Articles
1.
Li Z, Deeks S, Ott M, Greene W
Cell Rep
. 2023 Sep;
42(9):113055.
PMID: 37682714
Host repressors mediate HIV latency, but how they interactively silence the virus remains unclear. Here, we develop "reiterative enrichment and authentication of CRISPRi targets for synergies (REACTS)" to probe the...
2.
Li Z, Hajian C, Greene W
PLoS Pathog
. 2020 Dec;
16(12):e1009055.
PMID: 33270809
To counter HIV latency, it is important to develop a better understanding of the full range of host factors promoting latency. Their identification could suggest new strategies to reactivate latent...
3.
Li Z, Wu J, Chavez L, Hoh R, Deeks S, Pillai S, et al.
PLoS Pathog
. 2019 Jan;
15(1):e1007498.
PMID: 30645648
The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super...
4.
Li Z, Mbonye U, Feng Z, Wang X, Gao X, Karn J, et al.
PLoS Pathog
. 2018 Apr;
14(4):e1007012.
PMID: 29684085
The bromodomain protein Brd4 promotes HIV-1 latency by competitively inhibiting P-TEFb-mediated transcription induced by the virus-encoded Tat protein. Brd4 is recruited to the HIV LTR by interactions with acetyl-histones3 (AcH3)...
5.
Qi S, Li Z, Schulze-Gahmen U, Stjepanovic G, Zhou Q, Hurley J
Nat Commun
. 2017 Jan;
8:14076.
PMID: 28134250
The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å...
6.
Li Z, Lu H, Zhou Q
Mol Cell Biol
. 2016 Feb;
36(7):1194-205.
PMID: 26830226
Promoter-proximal pausing by RNA polymerase II (Pol II) is a key rate-limiting step in HIV-1 transcription and latency reversal. The viral Tat protein recruits human super elongation complexes (SECs) to...
7.
Lu H, Li Z, Zhang W, Schulze-Gahmen U, Xue Y, Zhou Q
Nucleic Acids Res
. 2015 May;
43(12):5868-79.
PMID: 26007649
The AF4/FMR2 proteins AFF1 and AFF4 act as a scaffold to assemble the Super Elongation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes. Although they can...
8.
Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson J, Krogan N, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
111(1):E15-24.
PMID: 24367103
The positive transcription elongation factor b (P-TEFb) stimulates RNA polymerase elongation by inducing the transition of promoter proximally paused polymerase II into a productively elongating state. P-TEFb itself is regulated...
9.
Lu H, Li Z, Xue Y, Zhou Q
Chem Rev
. 2013 Jun;
113(11):8567-82.
PMID: 23795863
No abstract available.
10.
Li Z, Guo J, Wu Y, Zhou Q
Nucleic Acids Res
. 2012 Oct;
41(1):277-87.
PMID: 23087374
Latent HIV reservoirs are the primary hurdle to eradication of infection. Identification of agents, pathways and molecular mechanisms that activate latent provirus may, in the presence of highly active antiretroviral...