Zhi Ying Zhao
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Explore the profile of Zhi Ying Zhao including associated specialties, affiliations and a list of published articles.
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6
Citations
163
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Recent Articles
1.
Zhu W, Liu J, Li W, Zhao Z, Huang C, Yang J, et al.
Cell Death Dis
. 2025 Jan;
16(1):13.
PMID: 39809779
Sterile alpha and Toll/interleukin-1 receptor motif containing 1 (SARM1), a nicotinamide adenine dinucleotide (NAD)-utilizing enzyme, mediates axon degeneration (AxD) in various neurodegenerative diseases. It is activated by nicotinamide mononucleotide (NMN)...
2.
He W, Yang J, Zhao Z, Xiao W, Li W, Zhao Y
Biology (Basel)
. 2024 Sep;
13(9).
PMID: 39336077
Glioblastoma, a formidable brain tumor characterized by dysregulated NAD metabolism, poses a significant therapeutic challenge. The NAMPT inhibitor FK866, which induces NAD depletion, has shown promise in controlling tumor proliferation...
3.
Hou Y, Cai Y, Li W, He W, Zhao Z, Zhu W, et al.
Nat Commun
. 2022 Dec;
13(1):7898.
PMID: 36550129
Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is an autoinhibitory NAD-consuming enzyme that is activated by the accumulation of nicotinamide mononucleotide (NMN) during axonal injury. Its...
4.
Zhao Y, He W, Zhao Z, Li W, Wang Q, Hou Y, et al.
FEBS J
. 2021 Jul;
288(23):6783-6794.
PMID: 34213829
SARM1, an executioner in axon degeneration, is an autoinhibitory NAD-consuming enzyme, composed of multiple domains. NMN and its analogs, CZ-48 and VMN, are the only known activators, which can release...
5.
Li W, Huang K, Cai Y, Wang Q, Zhu W, Hou Y, et al.
Elife
. 2021 May;
10.
PMID: 33944777
SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as...
6.
Zhao Z, Xie X, Li W, Liu J, Chen Z, Zhang B, et al.
iScience
. 2019 May;
15:452-466.
PMID: 31128467
SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca...
7.
Liu J, Zhao Y, Li W, Hou Y, Li T, Zhao Z, et al.
Proc Natl Acad Sci U S A
. 2017 Jul;
114(31):8283-8288.
PMID: 28720704
CD38 catalyzes the synthesis of the Ca messenger, cyclic ADP-ribose (cADPR). It is generally considered to be a type II protein with the catalytic domain facing outside. How it can...