Zhenhong Nan
Overview
Explore the profile of Zhenhong Nan including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
899
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0
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Recent Articles
1.
Belur L, Romero M, Lee J, Podetz-Pedersen K, Nan Z, Riedl M, et al.
Front Mol Neurosci
. 2021 May;
14:618360.
PMID: 34040503
Mucopolysaccharidosis type I (MPS I) is an inherited metabolic disorder caused by deficiency of the lysosomal enzyme alpha-L-iduronidase (IDUA). The two current treatments [hematopoietic stem cell transplantation (HSCT) and enzyme...
2.
Matyas J, Stewart A, Goldsmith A, Nan Z, Skeel R, Rossignol J, et al.
Cell Transplant
. 2017 Sep;
26(8):1472-1482.
PMID: 28901182
Spinal cord injury (SCI) is a widely disabling condition, constraining those affected by it to wheelchairs and requiring intense daily care and assistance. Cell replacement therapies, targeting regeneration of cells...
3.
Stewart A, Matyas J, Welchko R, Goldsmith A, Zeiler S, Hochgeschwender U, et al.
Restor Neurol Neurosci
. 2017 Jun;
35(4):395-411.
PMID: 28598857
Purpose: Utilizing genetic overexpression of trophic molecules in cell populations has been a promising strategy to develop cell replacement therapies for spinal cord injury (SCI). Over-expressing the chemokine, stromal derived...
4.
Laoharawee K, Podetz-Pedersen K, Nguyen T, Evenstar L, Kitto K, Nan Z, et al.
Hum Gene Ther
. 2017 May;
28(8):626-638.
PMID: 28478695
Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive lysosomal disorder caused by defective iduronate-2-sulfatase (IDS), resulting in accumulation of heparan sulfate and dermatan sulfate glycosaminoglycans (GAGs)....
5.
Stone L, Xiao F, Rotschafer J, Nan Z, Juliano M, Sanberg C, et al.
Cell Transplant
. 2016 Mar;
25(8):1473-88.
PMID: 26996530
Despite the high prevalence and devastating outcome, there remain a few options for treatment of ischemic stroke. Currently available treatments are limited by a short time window for treatment and...
6.
Janson C, Romanova L, Leone P, Nan Z, Belur L, McIvor R, et al.
Neurosurgery
. 2013 Oct;
74(1):99-111.
PMID: 24077583
Background: Hurler disease (mucopolysaccharidosis type I [MPS-I]) is an inherited metabolic disorder characterized by deficiency of the lysosomal enzyme α-L-iduronidase (IDUA). Currently, the only therapies for MPS-I, enzyme replacement and...
7.
Nan Z, Shekels L, Ryabinin O, Evavold C, Nelson M, Khan S, et al.
Cell Transplant
. 2012 Apr;
21(7):1577-93.
PMID: 22472595
Mucopolysaccharidosis type I (MPS-I; Hurler syndrome) is an inborn error of metabolism caused by lack of the functional lysosomal glycosaminoglycan (GAG)-degrading enzyme α-L-iduronidase (IDUA). Without treatment, the resulting GAG accumulation...
8.
Wolf D, Hanson L, Aronovich E, Nan Z, Low W, Frey 2nd W, et al.
Mol Genet Metab
. 2012 Mar;
106(1):131-4.
PMID: 22420937
Here we provide the first evidence that therapeutic levels of a lysosomal enzyme can bypass the blood-brain barrier following intranasal administration. α-L-iduronidase (IDUA) activity was detected throughout the brains of...
9.
Wolf D, Lenander A, Nan Z, Belur L, Whitley C, Gupta P, et al.
Neurobiol Dis
. 2011 Mar;
43(1):123-33.
PMID: 21397026
The mucopolysaccharidoses (MPSs) are a group of 11 storage diseases caused by disruptions in glycosaminoglycan (GAG) catabolism, leading to their accumulation in lysosomes. Resultant multisystemic disease is manifested by growth...
10.
Zu T, Gibbens B, Doty N, Gomes-Pereira M, Huguet A, Stone M, et al.
Proc Natl Acad Sci U S A
. 2010 Dec;
108(1):260-5.
PMID: 21173221
Trinucleotide expansions cause disease by both protein- and RNA-mediated mechanisms. Unexpectedly, we discovered that CAG expansion constructs express homopolymeric polyglutamine, polyalanine, and polyserine proteins in the absence of an ATG...