Zheng D Lan
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Explore the profile of Zheng D Lan including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
1259
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Recent Articles
1.
Shim H, Iaconelli J, Shang X, Li J, Lan Z, Jiang S, et al.
Cell
. 2024 Jun;
187(15):4030-4042.e13.
PMID: 38908367
Insufficient telomerase activity, stemming from low telomerase reverse transcriptase (TERT) gene transcription, contributes to telomere dysfunction and aging pathologies. Besides its traditional function in telomere synthesis, TERT acts as a...
2.
Shim H, Horner J, Wu C, Li J, Lan Z, Jiang S, et al.
Nat Aging
. 2022 Jan;
1(12):1162-1174.
PMID: 35036927
Amyloid-induced neurodegeneration plays a central role in Alzheimer's disease (AD) pathogenesis. Here, we show that haploinsufficiency decreases BDNF and increases amyloid-β (Aβ) precursor in murine brain. Moreover, prior to disease...
3.
Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, et al.
Cancer Cell
. 2018 Jan;
33(1):152.
PMID: 29316430
No abstract available.
4.
Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, et al.
Cancer Cell
. 2017 Jul;
32(1):42-56.e6.
PMID: 28697342
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased...
5.
Hu B, Wang Q, Wang Y, Hua S, Gabriel Sauve C, Ong D, et al.
Cell
. 2016 Nov;
167(5):1281-1295.e18.
PMID: 27863244
Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. To illuminate mechanisms governing these hallmark features, we developed a de novo glioblastoma multiforme (GBM) model derived...
6.
Lan Z, Tatsui C, Jalali A, Humphries W, Rilea K, Patel A, et al.
J Clin Neurosci
. 2015 Mar;
22(6):964-8.
PMID: 25800940
We describe a minimalist approach to perform in situ decompression of the ulnar nerve. Our technique employs a unique small skin incision strategically placed to minimize postoperative scarring over the...