Zhang-Hua Yang
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Explore the profile of Zhang-Hua Yang including associated specialties, affiliations and a list of published articles.
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14
Citations
1748
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Recent Articles
1.
Hong M, Wu X, He P, Peng R, Li L, Wu S, et al.
Cell Rep
. 2024 Nov;
43(11):114966.
PMID: 39520684
The pro-form of caspase-8 prevents necroptosis by functioning in a proteolytically active complex with its catalytic-dead homolog, FLICE (FADD [Fas-associated death domain]-like interleukin 1β-converting enzyme)-like inhibitory protein long-form (FLIP). However,...
2.
He P, Ai T, Qiao M, Yang Z, Han J
Cell Death Discov
. 2024 May;
10(1):255.
PMID: 38789425
Caspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 (T265), which can...
3.
Cai Z, Wu P, Liang H, Xie Y, Zhang B, He C, et al.
Cell Rep
. 2024 May;
43(5):114221.
PMID: 38748877
ZBP1 is an interferon (IFN)-induced nucleic acid (NA) sensor that senses unusual Z-form NA (Z-NA) to promote cell death and inflammation. However, the mechanisms that dampen ZBP1 activation to fine-tune...
4.
Wu X, Yang Z, Zheng Y, Wu J, Han J
Cell Mol Immunol
. 2024 Apr;
21(6):634-637.
PMID: 38632384
No abstract available.
5.
Wu X, Yang Z, Wu J, Han J
Immunity
. 2023 Mar;
56(5):926-943.e7.
PMID: 36948192
NOD-like receptors (NLRs) are pattern recognition receptors for diverse innate immune responses. Self-oligomerization after engagement with a ligand is a generally accepted model for the activation of each NLR. We...
6.
Li X, Zhang P, Yin Z, Xu F, Yang Z, Jin J, et al.
Research (Wash D C)
. 2022 Aug;
2022:9838341.
PMID: 35958114
Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease...
7.
8.
He P, Ai T, Yang Z, Wu J, Han J
STAR Protoc
. 2021 Jan;
2(1):100251.
PMID: 33458710
TNF-induced necroptosis is involved in many physiological and pathological processes. Phospho-MLKL is a hallmark of necroptosis. Cecum is a sensitive organ with extensive necroptosis responses to TNF . Here, taking...
9.
Li X, Zhong C, Wu R, Xu X, Yang Z, Cai S, et al.
Protein Cell
. 2021 Jan;
12(11):858-876.
PMID: 33389663
There remains a significant gap in our quantitative understanding of crosstalk between apoptosis and necroptosis pathways. By employing the SWATH-MS technique, we quantified absolute amounts of up to thousands of...
10.
Yang Z, Wu X, He P, Wang X, Wu J, Ai T, et al.
Mol Cell
. 2020 Sep;
80(2):296-310.e6.
PMID: 32979304
Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. It has been unclear how the Casp8 blockade of necroptosis is...