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» Authors » Zahid Shafiq

Zahid Shafiq

Explore the profile of Zahid Shafiq including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 118
Citations 638
Followers 0
Related Specialties
Chemistry
Biochemistry
Science
Top 10 Co-Authors
Ajmal Khan
Ahmed Al-Harrasi
Muhammad Yaqub
Muhammad Khalid
Saeed Ullah
Sobia Ahsan Halim
M Nawaz Tahir
Jamshed Iqbal
Parham Taslimi
Javid Hussain
Published In
RSC Adv
Bioorg Chem
Sci Rep
Acta Crystallogr Sect E Struct Rep Online
ACS Omega
Affiliations
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Recent Articles
1.
Design, synthesis, in-vitro and in-silico studies of novel N-heterocycle based hydrazones as α-glucosidase inhibitors
Farooqi R, Ullah S, Khan A, Gurav S, Mali S, Aftab H, et al.
Bioorg Chem . 2025 Jan; 156:108155. PMID: 39826499
Diabetes mellitus has dominated the globe as a chronic health condition and has become a major global health concern. The inhibition of the key metabolic enzymes of carbohydrates digestion including...
2.
Design, synthesis, , and studies of novel isatin-hybrid hydrazones as potential triple-negative breast cancer agents
Munir I, Batool Z, Khan F, Hussain J, Khan A, Mali S, et al.
RSC Adv . 2025 Jan; 15(2):948-965. PMID: 39807200
Recent advances in cancer therapy have been made possible by monoclonal antibodies, domain antibodies, antibody drug conjugates, The most impact has come from controlling cell cycle checkpoints through checkpoint inhibitors....
3.
Synthesis, biological evaluation, and in silico studies of phenyl naphthalene-2-sulfonate derived thiosemicarbazones as potential carbonic anhydrase inhibitors
Eshal J, Tariq H, Li J, Aftab H, Senol H, Taslimi P, et al.
Bioorg Chem . 2025 Jan; 155():108118. PMID: 39793219
A series of novel phenyl naphthalene-2-sulfonate-based thiosemicarbazones (5a-v) were synthesized and evaluated for their inhibitory activity against human carbonic anhydrases I and II (hCA I and hCA II). Compounds 5d...
4.
Design, synthesis, in vitro, and in silico studies of 4-fluorocinnamaldehyde based thiosemicarbazones as urease inhibitors
Islam M, Ullah S, Khan A, Batool Z, Mali S, Gurav S, et al.
Sci Rep . 2025 Jan; 15(1):609. PMID: 39753613
Clinically significant problems such as kidney stones and stomach ulcers are linked to the activation of the urease enzyme. At low pH, this enzyme gives an ideal environment to Helicobacter...
5.
Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors
Batool Z, Ullah S, Khan A, Mali S, Gurav S, Jawarkar R, et al.
Sci Rep . 2024 Oct; 14(1):25754. PMID: 39468115
Tyrosinase is an enzyme crucial for the progression of melanogenesis. Immoderate production of melanin may be the cause of hyperpigmentation and darkening leading to skin diseases. Tyrosinase is the most...
6.
Exploring the photovoltaic properties of naphthalene-1,5-diamine-based functionalized materials in aprotic polar medium: a combined experimental and DFT approach
Shafiq I, Khalid M, Jawaria R, Shafiq Z, Murtaza S, Braga A
RSC Adv . 2024 Oct; 14(45):33048-33060. PMID: 39434999
In this study, a series of naphthalene-1,5-diamine-based donor chromophores (ND1-ND9) with A-D-A architecture was synthesized through a condensation reaction between amines and substituted aldehydes. Various spectroscopic techniques , FTIR, UV-Vis,...
7.
Synthesis of 2,4-Bis(trifluoromethyl)benzaldehyde Hybrid Thiosemicarbazones as Prolyl Oligopeptidase Inhibitors for Neurodegenerative Disorders and their In-silico Analysis
Pasha A, Ullah S, Ahsan Halim S, Khan A, Hussain J, F E, et al.
Curr Med Chem . 2024 Oct; PMID: 39411949
Introduction: Prolyl-specific oligopeptidase (POP), one of the brain's highly expressed enzymes, is an important target for the therapy of central nervous system disorders, notably autism spectrum disorder, schizophrenia, Parkinson's, Alzheimer's...
8.
Synthesis, biological evaluation and studies of novel pyrrolidine derived thiosemicarbazones as dihydrofolate reductase inhibitors
Aftab H, Ullah S, Khan A, Al-Rashida M, Islam T, Alshammari A, et al.
RSC Adv . 2024 Oct; 14(43):31409-31421. PMID: 39380649
Dihydrofolate reductase (DHFR) is a crucial enzyme involved in folate metabolism and serves as a prime target for anticancer and antimicrobial therapies. In this study, a series of 4-pyrrolidine-based thiosemicarbazones...
9.
Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase
Aftab H, Ullah S, Khan A, Al-Rashida M, Islam T, Dahlous K, et al.
Sci Rep . 2024 Sep; 14(1):22645. PMID: 39349528
Dihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a promising target for drug development against various diseases, including cancer and tuberculosis. Herein, we present an integrated approach combining...
10.
Morpholine-tethered Novel Hydrazones as Promising Non-peptidic Prolyl Oligopeptidase (POP) Inhibitors: Synthesis In Vitro and In Silico Studies
Khalid U, Fatima N, Ullah S, Ahsan Halim S, Khan A, Mali S, et al.
Curr Med Chem . 2024 Sep; PMID: 39318003
Introduction: Prolyl oligopeptidase (POP) is a pivotal druggable target implicated in diverse biological processes and linked to the development of various ailments, including neurodegenerative disorders. While conventional peptide-based inhibitors have...