Zackary R Fitzsimonds
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Explore the profile of Zackary R Fitzsimonds including associated specialties, affiliations and a list of published articles.
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11
Citations
143
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Recent Articles
1.
Taner H, Gong W, Fitzsimonds Z, Li Z, Wu Y, He Y, et al.
bioRxiv
. 2024 Dec;
PMID: 39713429
Squamous cell carcinomas (SCC) are often preceded by potentially malignant precursor lesions, most of which remain benign. The terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor...
2.
Luo X, Qiu Y, Fitzsimonds Z, Wang Q, Chen Q, Lei Y
Oncogene
. 2024 Jan;
43(6):388-394.
PMID: 38177410
Tumor immune evasion is a hallmark of Head and Neck Cancers. The advent of immune checkpoint inhibitors (ICIs) in the first-line setting has transformed the management of these tumors. Unfortunately,...
3.
Heath B, Gong W, Taner H, Broses L, Okuyama K, Cheng W, et al.
Cell Rep
. 2023 Mar;
42(4):112303.
PMID: 36952341
Oncogenes destabilize STING in epithelial cell-derived cancer cells, such as head and neck squamous cell carcinomas (HNSCCs), to promote immune escape. Despite the abundance of tumor-infiltrating myeloid cells, HNSCC presents...
4.
Hinson A, Hawkes C, Blake C, Fitzsimonds Z, Zhu B, Buck G, et al.
Infect Immun
. 2022 Aug;
90(10):e0024722.
PMID: 36040155
The oral epithelial barrier acts as both a physical barrier to the abundant oral microbiome and a sentry for the immune system that, in health, constrains the accumulation of the...
5.
Lamont R, Fitzsimonds Z, Wang H, Gao S
Periodontol 2000
. 2022 Mar;
89(1):154-165.
PMID: 35244980
Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs compositionally from precancerous and healthy tissues. Though causality is yet to be definitively established, emerging trends implicate periodontal...
6.
Perpich J, Yakoumatos L, Johns P, Stocke K, Fitzsimonds Z, Wilkey D, et al.
Mol Oral Microbiol
. 2021 Jul;
36(5):258-266.
PMID: 34241965
Phosphorylation of proteins is a key component of bacterial signaling systems that can control important functions such as community development and virulence. We report here the identification of a Ubiquitous...
7.
Liu C, Stocke K, Fitzsimonds Z, Yakoumatos L, Miller D, Lamont R
PLoS Pathog
. 2021 May;
17(5):e1009598.
PMID: 34015051
Tyrosine phosphatases are often weaponized by bacteria colonizing mucosal barriers to manipulate host cell signal transduction pathways. Porphyromonas gingivalis is a periodontal pathogen and emerging oncopathogen which interferes with gingival...
8.
Fitzsimonds Z, Liu C, Stocke K, Yakoumatos L, Shumway B, Miller D, et al.
ISME J
. 2021 Mar;
15(9):2627-2642.
PMID: 33731837
At mucosal barriers, the virulence of microbial communities reflects the outcome of both dysbiotic and eubiotic interactions with the host, with commensal species mitigating or potentiating the action of pathogens....
9.
Shen D, Perpich J, Stocke K, Yakoumatos L, Fitzsimonds Z, Liu C, et al.
Mol Oral Microbiol
. 2020 Sep;
35(6):231-239.
PMID: 32940001
Porphyromonas gingivalis expresses a limited number of two-component systems, including RprY, an orphan response regulator which lacks a cognate sensor kinase. In this study, we examined cross-phosphorylation of RprY on...
10.
Jung Y, Miller D, Perpich J, Fitzsimonds Z, Shen D, Ohshima J, et al.
mBio
. 2019 Sep;
10(5).
PMID: 31551334
Protein-tyrosine phosphorylation in bacteria plays a significant role in multiple cellular functions, including those related to community development and virulence. Metal-dependent protein tyrosine phosphatases that belong to the polymerase and...