Zachary M Zigmond
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Explore the profile of Zachary M Zigmond including associated specialties, affiliations and a list of published articles.
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11
Citations
51
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Recent Articles
1.
Stoyell-Conti F, Suresh Kumar M, Zigmond Z, Rojas M, Santos Falcon N, Martinez L, et al.
Atherosclerosis
. 2024 Sep;
397:118582.
PMID: 39260002
Background And Aims: Lysyl oxidase (LOX) catalyzes the crosslinking of collagen and elastin to maintain tensile strength and structural integrity of the vasculature. Excessive LOX activity increases vascular stiffness and...
2.
Rojas M, Pereira-Simon S, Zigmond Z, Varona Santos J, Perla M, Santos Falcon N, et al.
Cells
. 2024 May;
13(10).
PMID: 38786017
Arteries and veins develop different types of occlusive diseases and respond differently to injury. The biological reasons for this discrepancy are not well understood, which is a limiting factor for...
3.
Rojas M, Zigmond Z, Pereira-Simon S, Santos Falcon N, Suresh Kumar M, Stoyell-Conti F, et al.
PLoS One
. 2024 Jan;
19(1):e0296264.
PMID: 38206912
The venous system has been historically understudied despite its critical roles in blood distribution, heart function, and systemic immunity. This study dissects the microanatomy of upper arm veins at the...
4.
Martinez L, Rojas M, Tabbara M, Pereira-Simon S, Santos Falcon N, Rauf M, et al.
Kidney Int Rep
. 2023 Apr;
8(4):837-850.
PMID: 37069981
Introduction: The molecular transformation of the human preaccess vein after arteriovenous fistula (AVF) creation is poorly understood. This limits our ability to design efficacious therapies to improve maturation outcomes. Methods:...
5.
Labissiere X, Zigmond Z, Challa A, Montoya C, Manzur-Pineda K, Abraham A, et al.
Front Cardiovasc Med
. 2022 Nov;
9:1005030.
PMID: 36419492
Background: Chronic kidney disease (CKD) is a highly comorbid condition with significant effects on vascular health and remodeling. Upper extremity veins are important in end-stage kidney disease (ESKD) due to...
6.
Falero-Diaz G, Barboza C, Pires F, Fanchin M, Ling J, Zigmond Z, et al.
Arterioscler Thromb Vasc Biol
. 2021 Dec;
42(2):175-188.
PMID: 34879707
Objective: Monocytes, which play an important role in arteriogenesis, can build immunologic memory by a functional reprogramming that modifies their response to a second challenge. This process, called trained immunity,...
7.
Zigmond Z, Song L, Martinez L, Lassance-Soares R, Velazquez O, Vazquez-Padron R
Atherosclerosis
. 2021 Mar;
324:133-140.
PMID: 33781566
Background And Aims: Increased receptor tyrosine kinase (RTK) activity has been historically linked to atherosclerosis. Paradoxically, we recently found that global deficiency in c-Kit function increased atherosclerosis in hyperlipidemic mice....
8.
Martinez L, Li X, Ramos-Echazabal G, Faridi H, Zigmond Z, Santos Falcon N, et al.
J Immunol
. 2020 Sep;
205(9):2545-2553.
PMID: 32938725
Pharmacological activation of integrin CD11b/CD18 (αβ, Mac-1, and CR3) shows anti-inflammatory benefits in a variety of animal models of human disease, and it is a novel therapeutic strategy. Reasoning that...
9.
Song L, Zigmond Z, Martinez L, Lassance-Soares R, Macias A, Velazquez O, et al.
Am J Physiol Heart Circ Physiol
. 2019 Aug;
317(4):H867-H876.
PMID: 31441677
Atherosclerosis is the most common underlying cause of cardiovascular morbidity and mortality worldwide. c-Kit (CD117) is a member of the receptor tyrosine kinase family, which regulates differentiation, proliferation, and survival...
10.
Hernandez D, Rojas M, Martinez L, Rodriguez B, Zigmond Z, Vazquez-Padron R, et al.
Biochem Biophys Res Commun
. 2019 Aug;
518(2):227-232.
PMID: 31416613
Introduction: Receptor tyrosine kinases have been implicated in various vascular remodeling processes and cardiovascular disease. However, their role in the regulation of vascular tone is poorly understood. Herein, we evaluate...