Yves Mechulam
Overview
Explore the profile of Yves Mechulam including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1031
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Recent Articles
1.
Paupelin-Vaucelle H, Boschiero C, Lazennec-Schurdevin C, Schmitt E, Mechulam Y, Marliere P, et al.
ACS Omega
. 2025 Feb;
10(5):4548-4560.
PMID: 39959092
We report the construction of an alternative protein priming system to recode genetic translation in by designing, through trial and error, a chimeric initiator whose sequence identity points partly to...
2.
Bourgeois G, Coureux P, Lazennec-Schurdevin C, Madru C, Gaillard T, Duchateau M, et al.
Nat Commun
. 2025 Jan;
16(1):348.
PMID: 39753558
The archaeal ribosome is of the eukaryotic type. TACK and Asgard superphyla, the closest relatives of eukaryotes, have ribosomes containing eukaryotic ribosomal proteins not found in other archaea, eS25, eS26...
3.
Fedry J, Silva J, Vanevic M, Fronik S, Mechulam Y, Schmitt E, et al.
Mol Cell
. 2024 Feb;
84(6):1078-1089.e4.
PMID: 38340715
Aberrantly slow ribosomes incur collisions, a sentinel of stress that triggers quality control, signaling, and translation attenuation. Although each collision response has been studied in isolation, the net consequences of...
4.
Opuu V, Nigro G, Lazennec-Schurdevin C, Mechulam Y, Schmitt E, Simonson T
Protein Sci
. 2023 Jul;
32(9):e4738.
PMID: 37518893
Amino acids (AAs) with a noncanonical backbone would be a valuable tool for protein engineering, enabling new structural motifs and building blocks. To incorporate them into an expanded genetic code,...
5.
Cardenal Peralta C, Vandroux P, Neumann-Arnold L, Panvert M, Fagart J, Seufert W, et al.
J Struct Biol
. 2023 Jul;
215(3):108006.
PMID: 37507029
Eukaryotic initiation factor 2 (eIF2) plays a key role in protein synthesis and in its regulation. The assembly of this heterotrimeric factor is facilitated by Cdc123, a member of the...
6.
Fedry J, Silva J, Vanevic M, Fronik S, Mechulam Y, Schmitt E, et al.
bioRxiv
. 2023 Mar;
PMID: 36993420
Aberrantly slow mRNA translation leads to ribosome stalling and subsequent collision with the trailing neighbor. Ribosome collisions have recently been shown to act as stress sensors in the cell, with...
7.
Kazan R, Bourgeois G, Lazennec-Schurdevin C, Coureux P, Mechulam Y, Schmitt E
Biochimie
. 2023 Feb;
217:31-41.
PMID: 36773835
In eukaryotes and in archaea late steps of translation initiation involve the two initiation factors e/aIF5B and e/aIF1A. These two factors are also orthologous to the bacterial IF2 and IF1...
8.
Kazan R, Bourgeois G, Carisetti D, Florea I, Larquet E, Maurice J, et al.
Front Mol Biosci
. 2022 Sep;
9:910218.
PMID: 36060254
Sample preparation on cryo-EM grids can give various results, from very thin ice and homogeneous particle distribution (ideal case) to unwanted behavior such as particles around the "holes" or complexes...
9.
Gabel F, Engilberge S, Schmitt E, Thureau A, Mechulam Y, Perez J, et al.
Acta Crystallogr D Struct Biol
. 2022 Sep;
78(Pt 9):1120-1130.
PMID: 36048152
Small-angle X-ray scattering (SAXS) has become an indispensable tool in structural biology, complementing atomic-resolution techniques. It is sensitive to the electron-density difference between solubilized biomacromolecules and the buffer, and provides...
10.
Kazan R, Bourgeois G, Lazennec-Schurdevin C, Larquet E, Mechulam Y, Coureux P, et al.
Nucleic Acids Res
. 2022 Jun;
50(11):6532-6548.
PMID: 35694843
In eukaryotes and in archaea late steps of translation initiation involve the two initiation factors e/aIF5B and e/aIF1A. In eukaryotes, the role of eIF5B in ribosomal subunit joining is established...