Yutaro Hama
Overview
Explore the profile of Yutaro Hama including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
494
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Recent Articles
1.
Maruyama T, Hama Y, Noda N
J Biochem
. 2023 Nov;
175(2):167-178.
PMID: 38016932
The cytoplasm of eukaryotes is dynamically zoned by membrane-bound and membraneless organelles. Cytoplasmic zoning allows various biochemical reactions to take place at the right time and place. Mitochondrion is a...
2.
Hama Y, Ogasawara Y, Noda N
Cancer Sci
. 2023 Apr;
114(7):2699-2708.
PMID: 37010190
Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to cellular homeostasis through the turnover of various biomolecules and organelles, often in a selective manner. Autophagy is closely...
3.
Hama Y, Morishita H, Mizushima N
EMBO Rep
. 2022 Jan;
23(2):e53894.
PMID: 35044051
The endoplasmic reticulum (ER) is a central hub for the biogenesis of various organelles and lipid-containing structures. Recent studies suggest that vacuole membrane protein 1 (VMP1) and transmembrane protein 41B...
4.
Zhang S, Hama Y, Mizushima N
J Cell Sci
. 2021 Jul;
134(13).
PMID: 34228793
Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across eukaryotes. Autophagy-related (ATG) genes have undergone extensive multiplications and losses in different eukaryotic lineages, resulting in functional diversification...
5.
Hama Y, Zhang S, Mizushima N
EMBO J
. 2021 Jun;
40(15):e108777.
PMID: 34169552
Selective autophagy relies on adaptor proteins to bind and transport cargos (or substrates) to the lysosome or vacuole, yet the mechanisms for cargo recognition are not well understood. In this...
6.
Okawa F, Hama Y, Zhang S, Morishita H, Yamamoto H, Levine T, et al.
J Cell Sci
. 2021 Mar;
134(8).
PMID: 33771928
TMEM41B and VMP1 are endoplasmic reticulum (ER)-localizing multi-spanning membrane proteins required for ER-related cellular processes such as autophagosome formation, lipid droplet homeostasis and lipoprotein secretion in eukaryotes. Both proteins have...
7.
Nozaki M, Otomo A, Mitsui S, Ono S, Shirakawa R, Chen Y, et al.
eNeurologicalSci
. 2020 Dec;
22:100301.
PMID: 33319079
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are genetically, pathologically and clinically-related progressive neurodegenerative diseases. Thus far, several variations have been identified in patients with ALS and FTD. However,...
8.
Morita K, Hama Y, Mizushima N
Autophagy
. 2019 Feb;
15(5):922-923.
PMID: 30773971
Macroautophagy/autophagy requires many autophagy-related (ATG) proteins. Most of the ATG genes were identified by genetic screening using simple model organisms. Recently, we performed a forward genetic screen in mammalian cells...
9.
Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, et al.
J Cell Biol
. 2018 Aug;
217(11):3817-3828.
PMID: 30093494
Macroautophagy is an intracellular degradation process that requires multiple autophagy-related () genes. In this study, we performed a genome-wide screen using the autophagic flux reporter GFP-LC3-RFP and identified as a...
10.
Morishita H, Kaizuka T, Hama Y, Mizushima N
Autophagy
. 2017 Jan;
13(4):757-758.
PMID: 28121224
Macroautophagy is a catabolic process that delivers cytoplasmic components via the autophagosome to lysosomes for degradation. Measuring autophagic activity is critical to dissect molecular mechanisms and functions of autophagy but...