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Yutaka Natsumeda

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Articles 13
Citations 113
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Recent Articles
1.
Tarao K, Sekino Y, Nonaka T, Iida H, Inamori M, Nakajima A, et al.
Intern Med . 2015 Oct; 54(20):2545-50. PMID: 26466687
Objective: Right-sided type colonic diverticulosis has been predominant in Japan, in contrast to European counties where the left-sided type is predominant. Considering the recent change in the dietary habits of...
2.
Higurashi T, Endo H, Uchiyama T, Uchiyama S, Yamada E, Ohkubo H, et al.
Carcinogenesis . 2014 Jun; 35(9):2134-41. PMID: 24958593
Leptin, secreted by the adipose tissue and known to be related to obesity, is considered to be involved in the onset and progression of colorectal cancer. However, the exact role...
3.
Okano Y, Nezu U, Enokida Y, Lee M, Kinoshita H, Lezhava A, et al.
PLoS One . 2013 Sep; 8(9):e73794. PMID: 24040073
Purpose: The transcription factor NRF2 plays a pivotal role in protecting normal cells from external toxic challenges and oxidative stress, whereas it can also endow cancer cells resistance to anticancer...
4.
Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, et al.
Redox Rep . 2013 Feb; 18(1):12-9. PMID: 23394493
Fibromyalgia (FM) is characterized by generalized pain and chronic fatigue of unknown etiology. To evaluate the role of oxidative stress in this disorder, we measured plasma levels of ubiquinone-10, ubiquinol-10,...
5.
Higurashi T, Hosono K, Endo H, Takahashi H, Iida H, Uchiyama T, et al.
BMC Cancer . 2012 Sep; 12:413. PMID: 22992267
Background: Colorectal cancer (CRC) is one of the most commonly occurring neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden...
6.
Higurashi T, Endo H, Yoneda M, Hosono K, Sakai E, Takahashi H, et al.
Digestion . 2011 Nov; 84(4):306-14. PMID: 22041924
Background/aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by diffuse mucosal inflammation, traditionally regarded as being limited to the colorectum. Although several gastroduodenal lesions have also been...
7.
Inoue S, Watanuki Y, Kaneko T, Sato T, Miyazawa N, Kaneko T, et al.
BMJ Open . 2011 Oct; 1(1):e000105. PMID: 22021764
Objective: To determine the ideal conditions for use of the 23-valent pneumococcal polysaccharide vaccine (PPV23) in older outpatients with chronic pulmonary diseases. Design: Prospective cohort study. Participants: 1378 outpatients with...
8.
Nezu U, Tsunoda S, Yoshimura H, Kuwabara T, Tomura S, Seki Y, et al.
J Atheroscler Thromb . 2010 Aug; 17(10):1063-9. PMID: 20702974
Aim: A reduced risk of type 2 diabetes has been reported following treatment with pravastatin. Adiponectin is an adipocyte-derived protein that has an antidiabetic property. The objective of this study...
9.
Hurwitz H, Cohen R, McGovren J, Hirawat S, Petros W, Natsumeda Y, et al.
Cancer Chemother Pharmacol . 2006 Jul; 59(1):139-47. PMID: 16819636
Purpose: To assess the maximum tolerated dose, safety, and pharmacokinetic (PK) profile of escalating doses of the novel topoisomerase I (topo I) inhibitor edotecarin (J-107088) given as a 2-h intravenous...
10.
Huang Z, Liu S, Zhang L, Salem M, Greig G, Chan C, et al.
Life Sci . 2005 Nov; 78(23):2663-8. PMID: 16313925
Ibudilast ophthalmic solution exhibited an improved clinical efficacy over cromoglycate in the treatment of allergic conjunctivitis. To further characterize its principal mode of action, the phosphodiesterase (PDE) inhibitory profile of...