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Yun-Kyo Kim

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Articles 7
Citations 40
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Recent Articles
1.
Kim Y, Ramalho-Santos M
Stem Cell Reports . 2025 Feb; 20(3):102406. PMID: 39919752
Transcriptional profiling of stem cells came of age at the beginning of the century with the use of microarrays to analyze cell populations in bulk. Since then, stem cell transcriptomics...
2.
Kim Y, Collignon E, Martin S, Ramalho-Santos M
Trends Genet . 2024 Sep; 40(12):1032-1046. PMID: 39271397
Stem cells are the fundamental drivers of growth during development and adult organ homeostasis. The properties that define stem cells - self-renewal and differentiation - are highly biosynthetically demanding. In...
3.
Zhu M, Gu B, Thomas E, Huang Y, Kim Y, Tao H, et al.
Sci Adv . 2024 Jul; 10(29):eadl6366. PMID: 39028807
Physical processes ultimately shape tissue during development. Two emerging proposals are that cells migrate toward stiffer tissue (durotaxis) and that the extent of cell rearrangements reflects tissue phase, but it...
4.
DCruz R, Kim Y, Mulder J, Ibeh N, Jiang N, Tian Y, et al.
J Pathol . 2023 Sep; 261(4):385-400. PMID: 37772431
Congenital anomalies of the kidney and urinary tract (CAKUT) are characterised by a spectrum of structural and histologic abnormalities and are the major cause of childhood kidney failure. During kidney...
5.
Kim Y, Cho B, Cook D, Trcka D, Wrana J, Ramalho-Santos M
Cell Rep . 2023 Jan; 42(1):111978. PMID: 36640358
Hypertranscription supports biosynthetically demanding cellular states through global transcriptome upregulation. Despite its potential widespread relevance, documented examples of hypertranscription remain few and limited to early development. Here, we demonstrate that...
6.
Bulut-Karslioglu A, Jin H, Kim Y, Cho B, Guzman-Ayala M, Williamson A, et al.
Nat Commun . 2021 Aug; 12(1):4859. PMID: 34381042
Stem and progenitor cells undergo a global elevation of nascent transcription, or hypertranscription, during key developmental transitions involving rapid cell proliferation. The chromatin remodeler Chd1 mediates hypertranscription in pluripotent cells...
7.
Hayes K, Kim Y, Pera M
Stem Cells . 2021 May; 39(9):1137-1144. PMID: 33932319
Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of critical roles in mammalian embryonic development. Nodal is essential for the support of the peri-implantation epiblast...
8.
Rowan C, Li W, Martirosyan H, Erwood S, Hu D, Kim Y, et al.
Development . 2018 Jun; 145(13). PMID: 29945868
Normal kidney function depends on the proper development of the nephron: the functional unit of the kidney. Reciprocal signaling interactions between the stroma and nephron progenitor compartment have been proposed...