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Yumiko Yoshimura

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Recent Articles
1.
Tomioka R, Shigematsu N, Miyashita T, Takahashi Y, Yamamoto M, Yoshimura Y, et al.
eNeuro . 2024 Nov; 11(11). PMID: 39592219
The cortico-basal ganglia loop has traditionally been conceptualized as consisting of three distinct information networks: motor, limbic, and associative. However, this three-loop concept is insufficient to comprehensively explain the diverse...
2.
Sugimura T, Miyashita T, Yamamoto M, Kobayashi K, Yoshimura Y, Saito Y
eNeuro . 2024 Oct; 11(11). PMID: 39467649
The neural network, including the interstitial nucleus of Cajal (INC), functions as an oculomotor neural integrator involved in the control of vertical gaze holding. Impairment of the vestibulocerebellum (VC), including...
3.
Yoneda T, Kameyama K, Gotou T, Terata K, Takagi M, Yoshimura Y, et al.
iScience . 2024 Jul; 27(6):110145. PMID: 38952682
Plasticity during the critical period is important for the functional maturation of cortical neurons. While characteristics of plasticity are diverse among cortical layers, it is unknown whether critical period timing...
4.
Kawamura N, Osuka T, Kaneko R, Kishi E, Higuchi R, Yoshimura Y, et al.
eNeuro . 2023 Oct; 10(10). PMID: 37890993
Functional neural circuits in the cerebral cortex are established through specific neural connections between excitatory and various inhibitory cell types. However, the molecular mechanisms underlying synaptic partner recognition remain unclear....
5.
Young T, Yamamoto M, Kikuchi S, Yoshida A, Abe T, Inoue K, et al.
Nat Commun . 2023 Sep; 14(1):6077. PMID: 37770450
Excitatory spiny stellate neurons are prominently featured in the cortical circuits of sensory modalities that provide high salience and high acuity representations of the environment. These specialized neurons are considered...
6.
Yoneda T, Hayashi K, Yoshimura Y
Proc Natl Acad Sci U S A . 2023 Feb; 120(9):e2217011120. PMID: 36812195
Subplate neurons are early-born cortical neurons that transiently form neural circuits during perinatal development and guide cortical maturation. Thereafter, most subplate neurons undergo cell death, while some survive and renew...
7.
Takeda H, Yoshimura Y, Takagi M, Sato A, Kihara N, Choudhury M, et al.
Biochem Biophys Res Commun . 2022 Dec; 638:176-183. PMID: 36462491
Bromovalerylurea (BU), an acyl urea derivative, was originally developed as a hypnotic/sedative. We recently reported that BU at a dose of 50 mg/kg ameliorates sepsis, Parkinson's disease, and traumatic brain...
8.
Hirayama T, Kadooka Y, Tarusawa E, Saitoh S, Nakayama H, Hoshino N, et al.
Acta Neuropathol Commun . 2022 Nov; 10(1):172. PMID: 36447271
CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and maintaining cell identity by controlling gene expression. In the mature cerebellum, CTCF is...
9.
Osanai Y, Battulga B, Yamazaki R, Kouki T, Yatabe M, Mizukami H, et al.
Neurochem Res . 2022 Aug; 47(9):2815-2825. PMID: 35933550
An appropriate sensory experience during the early developmental period is important for brain maturation. Dark rearing during the visual critical period delays the maturation of neuronal circuits in the visual...
10.
Kimura R, Yoshimura Y
Sci Adv . 2021 Nov; 7(48):eabj9976. PMID: 34826242
Animals exhibit improved perception of lower-contrast visual objects after training. We explored this neuronal mechanism using multiple single-unit recordings from deep layers of the primary visual cortex (V1) of trained...