Yukako Hara
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Explore the profile of Yukako Hara including associated specialties, affiliations and a list of published articles.
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8
Citations
10
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Recent Articles
1.
Nunobiki S, Yoshimoto A, Ito M, Yonoichi S, Hara Y, Ishida Y, et al.
J Vet Med Sci
. 2025 Feb;
PMID: 39993733
Our previous reports showed that exposure to the neonicotinoid pesticide clothianidin (CLO) at a no-observed-adverse-effect-level (NOAEL) dose during fetal development and lactation in mice led to higher rates of maternal...
2.
Yoshimoto A, Nunobiki S, Ito M, Yonoichi S, Hara Y, Ishida Y, et al.
J Vet Med Sci
. 2025 Feb;
PMID: 39938891
Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN's adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to...
3.
Ishida Y, Yonoichi S, Hara Y, Shoda A, Kimura M, Murata M, et al.
J Vet Med Sci
. 2024 Feb;
86(3):333-339.
PMID: 38311400
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target,...
4.
Hara Y, Shoda A, Yonoichi S, Ishida Y, Murata M, Kimura M, et al.
J Vet Med Sci
. 2024 Feb;
86(3):340-348.
PMID: 38311399
Neonicotinoid pesticides (NNs) have been associated with numerous neurobehavioral effects in rodents, raising concerns about their impact on cognitive function. Clothianidin (CLO), a type of NN, was orally administered to...
5.
Yonoichi S, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, et al.
J Vet Med Sci
. 2024 Jan;
86(3):277-284.
PMID: 38267031
The mechanism by which the neonicotinoid pesticide clothianidin (CLO) disrupts the intestinal microbiota of experimental animals is unknown. We focused on α-defensins, which are regulators of the intestinal microbiota. Subchronic...
6.
Yonoichi S, Hirano T, Hara Y, Ishida Y, Shoda A, Kimura M, et al.
Toxicol Appl Pharmacol
. 2023 Dec;
482:116795.
PMID: 38160895
Recent research has demonstrated the toxicity of neonicotinoid pesticides (NNs) in mammals through their interaction with nicotinic acetylcholine receptors (nAChRs). These effects are reported to extend to the intestinal microbiota...
7.
Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, et al.
J Vet Med Sci
. 2023 Aug;
85(9):1023-1029.
PMID: 37544714
Neonicotinoid pesticides (NNs) transfer rapidly from mother to offspring, which exhibit neurobehavioral effects. However, no studies have investigated NNs' transgenerational effects. We exposed F0 generation mice (mothers) to a no-observed-adverse-effect...
8.
Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, et al.
J Vet Med Sci
. 2023 Mar;
85(4):486-496.
PMID: 36858607
Neonicotinoid pesticides (NN) were recently reported to exhibit adverse effects in higher vertebrates. Moreover, NNs are routinely transferred from mother to offspring, raising concerns about their effects on future generations....
9.
Kimura M, Shoda A, Murata M, Hara Y, Yonoichi S, Ishida Y, et al.
J Vet Med Sci
. 2023 Mar;
85(4):497-506.
PMID: 36858584
Diamide insecticides activate ryanodine receptors expressed in lepidopteran skeletal muscle and promote Ca release in the sarcoplasmic reticulum, causing abnormal contractions and paralysis, leading to death of the pest. Although...
10.
Murata M, Shoda A, Kimura M, Hara Y, Yonoichi S, Ishida Y, et al.
J Vet Med Sci
. 2023 Feb;
85(4):434-442.
PMID: 36806246
Recently, the effects of exposure to clothianidin (CLO) on the thymus and gut microbiota have become clear, but no report has examined its next-generation impacts. Pregnant C57BL/6N mice were administered...