Yuichi Nozaki
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Explore the profile of Yuichi Nozaki including associated specialties, affiliations and a list of published articles.
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75
Citations
1861
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Recent Articles
1.
Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M, et al.
Life (Basel)
. 2021 Mar;
11(2).
PMID: 33672864
The prevalence of obesity or metabolic syndrome is increasing worldwide (globally metabodemic). Approximately 25% of the adult general population is suffering from nonalcoholic fatty liver disease (NAFLD), which has become...
2.
Masaki N, Kawasaki Y, Nozaki Y, Yanase M
Hepatol Res
. 2020 Nov;
51(4):417-425.
PMID: 33217105
Aim: Direct-acting antivirals (DAAs) have dramatically changed the treatment of chronic hepatitis C. Their high efficacy helps in eradicating hepatitis C virus with few adverse events. Information on real-world use...
3.
Nozaki Y, Petersen M, Zhang D, Vatner D, Perry R, Abulizi A, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(14):8166-8176.
PMID: 32188779
Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen synthesis is unknown. We demonstrate that glucokinase (GCK)-mediated glucose phosphorylation is the...
4.
Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M, et al.
Int J Mol Sci
. 2020 Mar;
21(6).
PMID: 32168769
Liver-related diseases are the third-leading causes (9.3%) of mortality in type 2 diabetes (T2D) in Japan. T2D is closely associated with nonalcoholic fatty liver disease (NAFLD), which is the most...
5.
Perry R, Zhang D, Guerra M, Brill A, Goedeke L, Nasiri A, et al.
Nature
. 2020 Mar;
579(7798):279-283.
PMID: 32132708
Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 ...
6.
Kodama K, Kawaguchi T, Hyogo H, Nakajima T, Ono M, Seike M, et al.
J Gastroenterol Hepatol
. 2019 Jan;
34(9):1626-1632.
PMID: 30668889
Background And Aim: The prevalence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD-HCC) is increasing. Unfortunately, NAFLD frequently develops into HCC without liver cirrhosis. Therefore, we investigated...
7.
Kawaguchi T, Tokushige K, Hyogo H, Aikata H, Nakajima T, Ono M, et al.
Sci Rep
. 2018 Jul;
8(1):10434.
PMID: 29992975
The prognosis of patients with nonalcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) is intricately associated with various factors. We aimed to investigate the prognostic algorithm of NAFLD-HCC patients using a...
8.
Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes
Perry R, Peng L, Cline G, Wang Y, Rabin-Court A, Song J, et al.
Cell Metab
. 2017 Nov;
27(1):210-217.e3.
PMID: 29129786
Caloric restriction rapidly reverses type 2 diabetes (T2D), but the mechanism(s) of this reversal are poorly understood. Here we show that 3 days of a very-low-calorie diet (VLCD, one-quarter their...
9.
Kuramoto J, Arai E, Tian Y, Funahashi N, Hiramoto M, Nammo T, et al.
Carcinogenesis
. 2017 Apr;
38(3):261-270.
PMID: 28426876
The aim of this study was to clarify the significance of DNA methylation alterations during non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis. Single-CpG-resolution genome-wide DNA methylation analysis was performed on 264 liver tissue...
10.
Arai T, Misawa M, Arai M, Shinozaki M, Sakamoto K, Yajima Y, et al.
J Xray Sci Technol
. 2016 Dec;
25(3):403-415.
PMID: 27911350
Background: Currently, no standardized method for measuring intrahepatic fat density via conventional computed tomography (CT) exists. Objective: We aim to quantify intrahepatic fat density via material decomposition analysis using rapid...