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YuanZhi Lao

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Articles 33
Citations 686
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Recent Articles
1.
Zheng Z, Tan J, Zhang J, Wu M, Chen G, Li Z, et al.
Food Funct . 2022 Jan; 13(4):1741-1750. PMID: 35088780
The fruits of can be eaten raw or processed into spices, which are considered to possess nutritional and medicinal value. Neobractatin (NBT) is a natural compound isolated from . This...
2.
Han L, Xu D, Xi Z, Wu M, Nabil W, Zhang J, et al.
Front Pharmacol . 2021 Jan; 11:564833. PMID: 33390942
PPAPs (Polycyclic polyprenylated acylphloroglucinols) are a class of compounds with diverse bioactivities, including anticancer effects. Oblongifolin C (OC) is a PPAP isolated from the plant of Hu. We previously discovered...
3.
Xiang Q, Wu M, Zhang L, Fu W, Yang J, Zhang B, et al.
Front Pharmacol . 2020 May; 11:452. PMID: 32351391
Mitophagy is a crucial process in controlling mitochondrial biogenesis. Balancing mitophagy and mitochondrial functions is required for maintaining cellular homeostasis. In this study, we found that Gerontoxanthone I (GeX1) and...
4.
Li Y, Huang C, Fu W, Zhang H, Lao Y, Zhou H, et al.
J Ethnopharmacol . 2020 Feb; 253:112645. PMID: 32045684
Ethnopharmacological Relevance: The Coreopsis tinctoria Nutt. flower (CTF) has been used traditionally in China for treating hypertension and diabetes as well as reducing body weight and blood fat. However, the...
5.
Zheng Z, Wu M, Zhang J, Fu W, Xu N, Lao Y, et al.
Front Oncol . 2019 Aug; 9:654. PMID: 31380287
The complexity and multi-target feature of natural compounds have made it difficult to elucidate their mechanism of action (MoA), which hindered the development of lead anticancer compounds to some extent....
6.
Zhang J, Zheng Z, Wu M, Zhang L, Wang J, Fu W, et al.
Cell Death Dis . 2019 Jul; 10(8):554. PMID: 31320607
Tumor metastasis is the predominant cause of lethality in cancer. We found that Neobractatin (NBT), a natural compound isolated from Garcinia bracteata, could efficiently inhibit breast and lung cancer cells...
7.
Hu K, Yin F, Yu M, Sun C, Li J, Liang Y, et al.
Theranostics . 2018 Dec; 8(20):5660-5661. PMID: 30555571
[This corrects the article DOI: 10.7150/thno.19840.].
8.
Qiu Y, Sun Y, Xu D, Yang Y, Liu X, Wei Y, et al.
EBioMedicine . 2018 Oct; 37:344-355. PMID: 30348622
Background: The pharmacological activation of thermogenesis in brown adipose tissue has long been considered promising strategies to treat obesity. However, identification of safe and effective agents remains a challenge. In...
9.
Li Y, Xi Z, Chen X, Cai S, Liang C, Wang Z, et al.
Cell Death Dis . 2018 May; 9(5):538. PMID: 29749405
Gemcitabine (GEM)-induced drug resistance is the major reason for the failure of chemotherapy in pancreatic cancer (PC). In this study, we found that Oblongifolin C (OC) efficiently inhibited PC cell...
10.
Xu L, Meng X, Xu N, Fu W, Tan H, Zhang L, et al.
Cell Death Dis . 2018 Feb; 9(3):262. PMID: 29449529
Erlotinib resistance causes a high degree of lethality in non-small-cell lung cancer (NSCLC) patients. The high expression and activation of several receptor tyrosine kinases, such as JAK/STAT3, c-Met, and EGFR,...