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Yuan-Yuan Zhuang

Explore the profile of Yuan-Yuan Zhuang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 107
Followers 0
Related Specialties
Neurology
Molecular Biology
General Medicine
Top 10 Co-Authors
Xiao-Qing Tang
Heng-Rong Fang
Chun-Yan Wang
Yan-Kai Ren
Hong-Feng Gu
Cheng-Fang Zhou
Rong-Qian Chen
Ping Zhang
Bi Hu
Lei Wu
Published In
J Mol Neurosci
Neurochem Int
Clin Exp Pharmacol Physiol
PLoS One
Med Gas Res
Affiliations
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Recent Articles
1.
Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor
Li X, Zhuang Y, Wu L, Xie M, Gu H, Wang B, et al.
Neuropsychobiology . 2019 Sep; 79(2):119-130. PMID: 31550727
Objective: To investigate whether hydrogen sulfide (H2S) counteracts formaldehyde (FA)-induced cognitive defects and whether the underlying mechanism is involved in the upregulation of hippocampal brain-derived neurotrophic factor (BDNF) expression. Methods:...
2.
A novel mechanism of formaldehyde neurotoxicity: inhibition of hydrogen sulfide generation by promoting overproduction of nitric oxide
Tang X, Fang H, Zhou C, Zhuang Y, Zhang P, Gu H, et al.
PLoS One . 2013 Jan; 8(1):e54829. PMID: 23359814
Background: Formaldehyde (FA) induces neurotoxicity by overproduction of intracellular reactive oxygen species (ROS). Increasing studies have shown that hydrogen sulfide (H(2)S), an endogenous gastransmitter, protects nerve cells against oxidative stress...
3.
Formaldehyde impairs learning and memory involving the disturbance of hydrogen sulfide generation in the hippocampus of rats
Tang X, Zhuang Y, Zhang P, Fang H, Zhou C, Gu H, et al.
J Mol Neurosci . 2012 Oct; 49(1):140-9. PMID: 23108488
Formaldehyde (FA), a well-known indoor and outdoor pollutant, has been implicated as the responsible agent in the development of neurocognitive disorders. Hydrogen sulfide (H(2)S), the third gasotransimitter, is an endogenous...
4.
Hydrogen sulfide prevents formaldehyde-induced neurotoxicity to PC12 cells by attenuation of mitochondrial dysfunction and pro-apoptotic potential
Tang X, Ren Y, Zhou C, Yang C, Gu H, He J, et al.
Neurochem Int . 2012 May; 61(1):16-24. PMID: 22542418
Hydrogen sulfide (H(2)S) has been shown to act as a neuroprotectant and antioxidant. Numerous studies have demonstrated that exposure to formaldehyde (FA) causes neuronal damage and that oxidative stress is...
5.
ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function
Tang X, Chen R, Ren Y, Del Soldato P, Sparatore A, Zhuang Y, et al.
Med Gas Res . 2011 Dec; 1(1):20. PMID: 22146536
Background: The hydrogen sulfide-releasing sildenafil, ACS6, has been demonstrated to inhibit superoxide formation through donating hydrogen sulfide (H2S). We have found that H2S antagonizes homocysteine-induced oxidative stress and neurotoxicity. The...
6.
Involvement of K(ATP)/PI (3)K/AKT/Bcl-2 pathway in hydrogen sulfide-induced neuroprotection against the toxicity of 1-methy-4-phenylpyridinium ion
Tang X, Zhuang Y, Fan L, Fang H, Zhou C, Zhang P, et al.
J Mol Neurosci . 2011 Jul; 46(2):442-9. PMID: 21800153
We previously reported that hydrogen sulfide (H(2)S) produces protection in PC12 cells during 1-methy-4-phenylpyridinium ion (MPP(+)) challenge. The present study aims to clarify the mechanisms underlying the neuroprotective effects of...
7.
Formaldehyde induces neurotoxicity to PC12 cells involving inhibition of paraoxonase-1 expression and activity
Tang X, Ren Y, Chen R, Zhuang Y, Fang H, Xu J, et al.
Clin Exp Pharmacol Physiol . 2011 Jan; 38(4):208-14. PMID: 21261675
1. Formaldehyde (FA) has been found to cause toxicity to neurons. However, its neurotoxic mechanisms have not yet been clarified. Increasing evidence has shown that oxidative damage is one of...
8.
Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity: role of ERK1/2 activation
Tang X, Shen X, Huang Y, Chen R, Ren Y, Fang H, et al.
J Mol Neurosci . 2010 Nov; 45(1):60-7. PMID: 21104457
Both elevated homocysteine and decreased hydrogen sulfide (H(2)S) are observed in the brains of Alzheimer's disease (AD) patients. Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of homocysteine; however,...