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Yuan-Qiang Chen

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Recent Articles
1.
Li H, Chen Y, Li Y, Wei X, Wang S, Cao Y, et al.
Nat Commun . 2024 Jul; 15(1):5849. PMID: 38992001
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity...
2.
Chen Y, Xue M, Li J, Huo D, Ding H, Ma Y
ACS Nano . 2024 Feb; 18(8):6463-6476. PMID: 38346263
The cellular uptake of nanoparticles (NPs) by biological cells is an important and fundamental process in drug delivery. Previous studies reveal that the physicochemical properties of nanoparticles as well as...
3.
Zhao H, Chen Y, Luo X, Cai M, Li J, Lin X, et al.
ACS Nano . 2024 Jan; 18(3):2162-2183. PMID: 38198577
Neutral nanomaterials functionalized with PEG or similar molecules have been popularly employed as nanomedicines. Compared to positive counterparts that are capable of harnessing the well-known proton sponge effect to facilitate...
4.
Chen Y, Sheng Y, Ma Y, Ding H
Phys Chem Chem Phys . 2022 Jun; 24(23):14339-14347. PMID: 35642694
Protein-ligand interactions are crucial in many biochemical processes and biomedical applications, yet accurately calculating the binding free energy of the interactions still remains challenging. In this work, we systematically investigate...
5.
Ni S, Chen Y, Chen Y, Zhou K, Ding H
Langmuir . 2021 Sep; 37(40):11707-11715. PMID: 34570511
The unconjugated bilirubin (BR) may penetrate through the cell membrane and cause a severe cytotoxicity. However, the molecular mechanism underlying the penetration of BR into the cell membrane is still...