Yu-Chi Chou
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Explore the profile of Yu-Chi Chou including associated specialties, affiliations and a list of published articles.
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49
Citations
631
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Recent Articles
1.
Chen X, Mohapatra A, Nguyen H, Schimanski L, Tan T, Rijal P, et al.
PLoS Pathog
. 2024 Jun;
20(6):e1012246.
PMID: 38857264
Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from vaccinated and infected individuals and elucidate the mechanism of action of broadly...
2.
Munalisa R, Lien T, Tsai P, Sun D, Cheng C, Wu W, et al.
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791301
Psychological stress increases risk of gastrointestinal tract diseases. However, the mechanism behind stress-induced gastrointestinal injury is not well understood. The objective of our study is to elucidate the putative mechanism...
3.
Chang Y, Hsu M, Chen W, Wu M, Kong W, Lu M, et al.
JCI Insight
. 2024 May;
9(10).
PMID: 38775156
Since its emergence, SARS-CoV-2 has been continuously evolving, hampering the effectiveness of current vaccines against COVID-19. mAbs can be used to treat patients at risk of severe COVID-19. Thus, the...
4.
Huang C, Chiu S, Chou Y, Wu K
Biotechnol J
. 2024 Feb;
19(2):e2300353.
PMID: 38403398
Prime editing is an advanced technology in CRISPR/Cas research with increasing numbers of improved methodologies. The original multi-vector method hampers the efficiency and precision of prime editing and also has...
5.
Su W, Chen Z, Chang Y, Jeng K, Le U, Chou Y, et al.
Antiviral Res
. 2023 Nov;
220:105744.
PMID: 37944823
Working with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is restricted to biosafety level III (BSL-3) laboratory. The study used a trans-complementation system consisting of virus-like particles (VLPs) and DNA-launched replicons...
6.
Chou M, Wang Y, Chen F, Kung C, Wu K, Kuo J, et al.
Mol Cell
. 2023 Oct;
83(22):4123-4140.e12.
PMID: 37848033
Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency through compartmentalizing DNPS enzymes during stressed conditions. However, the mechanism underpinning purinosome assembly and its pathophysiological functions remains...
7.
Cheng L, Tan G, Chang F, Wang C, Chou Y, Hsu P, et al.
Sci Rep
. 2023 Oct;
13(1):17597.
PMID: 37845346
The intestinal epithelium is highly regenerative. Rapidly proliferating LGR5 crypt base columnar (CBC) cells are responsible for epithelial turnover needed to maintain intestinal homeostasis. Upon tissue damage, loss of LGR5...
8.
Hsieh Y, Chen Y, Chou Y, Kuo P, Yen Y, Tsai H, et al.
J Biomed Sci
. 2023 Sep;
30(1):78.
PMID: 37700342
Background: Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus erythematosus (SLE) patients with alveolar hemorrhage (AH). SNHG16, a lncRNA, can enhance pulmonary inflammation...
9.
Lu R, Liang K, Chiang H, Hsu F, Lin H, Chen W, et al.
Heliyon
. 2023 Apr;
9(5):e15587.
PMID: 37090428
The COVID-19 pandemic continues to threaten human health worldwide as new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge. Currently, the predominant circulating strains around the world...
10.
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Huang K, Chen X, Mohapatra A, Nguyen H, Schimanski L, Tan T, et al.
Nat Commun
. 2023 Jan;
14(1):311.
PMID: 36658148
Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated a panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited upon natural infection and vaccination and showed that...