Youn Sook Lee
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Explore the profile of Youn Sook Lee including associated specialties, affiliations and a list of published articles.
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17
Citations
563
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Recent Articles
1.
Kim S, Oh J, Roh W, Park J, Chung K, Lee G, et al.
J Allergy Clin Immunol
. 2023 Jan;
151(5):1317-1328.
PMID: 36646143
Background: Psoriasis is a chronically relapsing inflammatory skin disease primarily perpetuated by skin-resident IL-17-producing T (T17) cells. Pellino-1 (Peli1) belongs to a member of E3 ubiquitin ligase mediating immune receptor...
2.
Park J, Kim M, Song N, Kim J, Seo D, Lee J, et al.
Stem Cells
. 2018 Nov;
37(3):368-381.
PMID: 30444564
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into mature cells of various cell types. Although the differentiation process of MSCs requires lineage-specific transcription factors, the exact molecular...
3.
Kim J, Seo D, Kim S, Choi D, Park J, Ha J, et al.
EMBO Rep
. 2018 Mar;
19(4).
PMID: 29487085
Autophagy begins with the formation of autophagosomes, a process that depends on the activity of the serine/threonine kinase ULK1 (hATG1). Although earlier studies indicated that ULK1 activity is regulated by...
4.
Lee J, Jung S, Yang K, Bae E, Ahn S, Park J, et al.
Nat Cell Biol
. 2017 Sep;
19(10):1260-1273.
PMID: 28892081
Although the ubiquitin-editing enzyme A20 is a key player in inflammation and autoimmunity, its role in cancer metastasis remains unknown. Here we show that A20 monoubiquitylates Snail1 at three lysine...
5.
Lee J, Seo D, You J, Chung S, Park J, Lee J, et al.
FEBS Lett
. 2017 Jan;
591(3):479-490.
PMID: 28094437
NOD-like receptor family protein 3 (NLRP3)-mediated inflammasome activation promotes caspase-1-dependent production of interleukin-1β (IL-1β) and requires the adaptor protein ASC. Compared with the priming and activation mechanisms of the inflammasome...
6.
Park J, Yi T, Park J, Han Y, Kim J, Shin D, et al.
J Clin Biochem Nutr
. 2015 Nov;
57(3):192-203.
PMID: 26566304
Mouse bone marrow-derived clonal mesenchymal stem cells (mcMSCs), which were originated from a single cell by a subfractionation culturing method, are recognized as new paradigm for stem cell therapy featured...
7.
Lee Y, Park J, Jung S, Kim S, Kim J, Lee J, et al.
EMBO Mol Med
. 2015 Mar;
7(5):577-92.
PMID: 25766838
We have previously reported that Smad6, one of the inhibitory Smads of transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signaling, inhibits Toll-like receptor (TLR) 4 signaling by disrupting the Pellino-1-mediated...
8.
Jung S, Lee J, Park J, Oh Y, Lee S, Park J, et al.
Nat Commun
. 2013 Oct;
4:2562.
PMID: 24096742
Transforming growth factor (TGF)-β, a pivotal cytokine involved in a variety of cellular functions, transmits signals through Smad-dependent canonical and Smad-independent noncanonical pathways. In contrast to the canonical TGF-β pathway,...
9.
Lee Y, Park J, Kim J, Jung S, Lee J, Kim S, et al.
Nat Commun
. 2011 Sep;
2:460.
PMID: 21897371
Transforming growth factor-β (TGF-β) is a potent anti-inflammatory cytokine that regulates interleukin-1 receptor and Toll-like receptor (TLR) signalling. Here we show a novel mechanism where TGF-β1-induced K48-linked polyubiquitination and degradation...
10.
Kim J, Sung K, Jung S, Lee Y, Kwon J, Choi C, et al.
Mol Cells
. 2010 Dec;
31(1):85-9.
PMID: 21120624
Covalent modifications of the Pellino-1 protein are essential for transmitting innate immune response signals downstream, as the phosphorylation and polyubiquitination of Pellino-1 mediated by the IRAK proteins appear to have...