Yongsuk Ku
Overview
Explore the profile of Yongsuk Ku including associated specialties, affiliations and a list of published articles.
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5
Citations
56
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Recent Articles
1.
Aldonza M, Cha J, Yong I, Ku J, Sinitcyn P, Lee D, et al.
Elife
. 2023 Mar;
12.
PMID: 36961502
Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive. Here, we show that an elevated secretome fucosylation...
2.
Kang M, Kharbash R, Byun J, Jeon J, Ali A, Ku D, et al.
Mol Ther Nucleic Acids
. 2022 Aug;
29:370-383.
PMID: 36035755
Hypomethylating agents (HMAs), such as azacitidine and decitabine, induce cancer cell death by demethylating DNAs to promote the expression of tumor-suppressor genes. HMAs also reactivate the transcription of endogenous double-stranded...
3.
Ku Y, Park J, Cho R, Lee Y, Park H, Kim M, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(13).
PMID: 33762305
DNA-methyltransferase inhibitors (DNMTis), such as azacitidine and decitabine, are used clinically to treat myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Decitabine activates the transcription of endogenous retroviruses (ERVs), which...
4.
Kim S, Ku Y, Ku J, Kim Y
Bioessays
. 2019 May;
41(7):e1900023.
PMID: 31099409
Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their...
5.
Kunkeaw N, Lee Y, Im W, Jang J, Song M, Yang B, et al.
Proc Natl Acad Sci U S A
. 2019 Apr;
116(17):8289-8294.
PMID: 30948645
DNA-reactive compounds are harnessed for cancer chemotherapy. Their genotoxic effects are considered to be the main mechanism for the cytotoxicity to date. Because this mechanism preferentially affects actively proliferating cells,...