Yolanda Stypula-Cyrus
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Explore the profile of Yolanda Stypula-Cyrus including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
287
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0
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Recent Articles
1.
Bauer G, Stypula-Cyrus Y, Subramanian H, Cherkezyan L, Viswanathan P, Zhang D, et al.
Future Sci OA
. 2017 Sep;
3(3):FSO206.
PMID: 28884003
Morphological alterations of the nuclear texture are a hallmark of carcinogenesis. At later stages of disease, these changes are well characterized and detectable by light microscopy. Evidence suggests that similar...
2.
Almassalha L, Bauer G, Chandler J, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(42):E6372-E6381.
PMID: 27702891
The organization of chromatin is a regulator of molecular processes including transcription, replication, and DNA repair. The structures within chromatin that regulate these processes span from the nucleosomal (10-nm) to...
3.
Wali R, Momi N, Dela Cruz M, Calderwood A, Stypula-Cyrus Y, Almassalha L, et al.
Cancer Prev Res (Phila)
. 2016 Aug;
9(11):844-854.
PMID: 27549371
Alterations in high order chromatin, with concomitant modulation in gene expression, are one of the earliest events in the development of colorectal cancer. Cohesins are a family of proteins that...
4.
Dong B, Almassalha L, Stypula-Cyrus Y, Urban B, Chandler J, Nguyen T, et al.
Proc Natl Acad Sci U S A
. 2016 Aug;
113(35):9716-21.
PMID: 27535934
Visualizing the nanoscale intracellular structures formed by nucleic acids, such as chromatin, in nonperturbed, structurally and dynamically complex cellular systems, will help expand our understanding of biological processes and open...
5.
Chandler J, Stypula-Cyrus Y, Almassalha L, Bauer G, Bowen L, Subramanian H, et al.
J Biophotonics
. 2016 Apr;
10(3):377-384.
PMID: 27111884
A new multimodal confocal microscope has been developed, which includes a parallel Partial Wave Spectroscopic (PWS) microscopy path. This combination of modalities allows molecular-specific sensing of nanoscale intracellular structure using...
6.
Yi J, Stypula-Cyrus Y, Blaha C, Roy H, Backman V
Biophys J
. 2015 Dec;
109(11):2218-26.
PMID: 26636933
Chromatin organization has a fundamental impact on the whole spectrum of genomic functions. Quantitative characterization of the chromatin structure, particularly at submicron length scales where chromatin fractal globules are formed,...
7.
Yi J, Radosevich A, Stypula-Cyrus Y, Mutyal N, Azarin S, Horcher E, et al.
J Biomed Opt
. 2014 Mar;
19(3):36013.
PMID: 24643530
Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to...
8.
Cherkezyan L, Stypula-Cyrus Y, Subramanian H, White C, Dela Cruz M, Wali R, et al.
BMC Cancer
. 2014 Mar;
14:189.
PMID: 24629088
Background: Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field cancerization, the tissue...
9.
Stypula-Cyrus Y, Mutyal N, Dela Cruz M, Kunte D, Radosevich A, Wali R, et al.
FEBS Lett
. 2014 Feb;
588(5):829-35.
PMID: 24492008
End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression...
10.
Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy
Radosevich A, Mutyal N, Yi J, Stypula-Cyrus Y, Rogers J, Goldberg M, et al.
J Biomed Opt
. 2013 Sep;
18(9):097002.
PMID: 24008865
Optical characterization of biological tissue in field carcinogenesis offers a method with which to study the mechanisms behind early cancer development and the potential to perform clinical diagnosis. Previously, low-coherence...