Yoko Hosaka
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Explore the profile of Yoko Hosaka including associated specialties, affiliations and a list of published articles.
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11
Citations
297
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Recent Articles
1.
Nagata K, Shinozaki T, Yamada K, Ogura S, Yamamoto S, Ohnishi Y, et al.
J Orthop Sci
. 2021 Jul;
27(5):1056-1059.
PMID: 34325953
Background: Necrotizing fasciitis (NF) is a life-threatening and acute progressive soft tissue infection and needs early surgical intervention, that is, debridement or amputation. Surgical strategy or prognosis is influenced by...
2.
Kamekura S, Hosaka Y, Sasaki G, Miyamoto H, Kimura M, Hirota J
JBJS Case Connect
. 2021 Jun;
11(2).
PMID: 34115652
Case: We report a case of irreducible chronic volar dislocation of the distal radioulnar joint (DRUJ) after surgery for distal radius fracture. The patient underwent volar locking plate fixation for...
3.
Makii Y, Asaka M, Setogawa S, Fujiki S, Hosaka Y, Yano F, et al.
J Orthop Surg (Hong Kong)
. 2018 Apr;
26(2):2309499018768017.
PMID: 29661110
Purpose: Joint pain is the most common symptom of osteoarthritis (OA); however, its mechanism remains unclarified. The present study investigated hindlimb motion during locomotion on the treadmill using a three-dimensional...
4.
Kobayashi H, Chang S, Mori D, Itoh S, Hirata M, Hosaka Y, et al.
Nat Commun
. 2016 Nov;
7:13336.
PMID: 27830706
In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell survival and catabolic enzyme production. Here, we analyse in vivo functions...
5.
Taniguchi Y, Kawata M, Chang S, Mori D, Okada K, Kobayashi H, et al.
Arthritis Rheumatol
. 2016 Oct;
69(3):598-609.
PMID: 27792866
Objective: Transcription factor p63, of the p53 family, regulates cell proliferation, survival, and apoptosis in various cells and tissues. This study was undertaken to examine the expression and roles of...
6.
Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, et al.
Proc Natl Acad Sci U S A
. 2015 Mar;
112(10):3080-5.
PMID: 25733872
Notch signaling modulates skeletal formation and pathogenesis of osteoarthritis (OA) through induction of catabolic factors. Here we examined roles of Hes1, a transcription factor and important target of Notch signaling,...
7.
Okada K, Fukai A, Mori D, Hosaka Y, Yano F, Chung U, et al.
PLoS One
. 2014 Dec;
9(12):e115169.
PMID: 25546433
Transcription factors SOX9, SOX5 and SOX6 are indispensable for generation and differentiation of chondrocytes. However, molecular mechanisms to induce the SOX genes are poorly understood. To address this issue, we...
8.
Yano F, Ohba S, Hosaka Y, Saito T, Chung U
Ann Rheum Dis
. 2014 Aug;
73(11):2062-4.
PMID: 25135252
No abstract available.
9.
Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, et al.
Proc Natl Acad Sci U S A
. 2013 Jan;
110(5):1875-80.
PMID: 23319657
Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development. Intracellular domains of Notch1 and -2 were translocated into the...
10.
Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, et al.
Ann Rheum Dis
. 2012 Oct;
72(5):748-53.
PMID: 23041841
Objectives: To identify a new disease-modifying osteoarthritis drug (DMOAD) candidate that can effectively repair cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression by suppressing aberrant hypertrophy. Methods: We...