Yitao Ou
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Explore the profile of Yitao Ou including associated specialties, affiliations and a list of published articles.
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20
Citations
271
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Recent Articles
1.
Yang X, Lin G, Chen Y, Lei X, Ou Y, Yan Y, et al.
ACS Cent Sci
. 2024 Sep;
10(9):1789-1802.
PMID: 39345816
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited treatment options. Thus, it is essential to investigate potential druggable targets to improve IPF treatment outcomes. By screening...
2.
Ou Y, Yang Z, Zhou Y, Yue H, Hua L, Liu Z, et al.
Eur J Pharmacol
. 2024 Jan;
965:176331.
PMID: 38220140
Inflammatory bowel disease (IBD) is a condition characterized by inflammation in the gastrointestinal tract. Reducing intestinal inflammation is a promising approach for treating IBD. The nucleotide-binding oligomerization domain-like receptor family...
3.
Zhou Y, Yang Z, Ou Y, Cai H, Liu Z, Lin G, et al.
Cell Mol Life Sci
. 2023 Jul;
80(8):230.
PMID: 37498355
The aberrant activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is known to contribute to the pathogenesis of various human inflammation-related diseases. However, to...
4.
Hua L, Liang S, Zhou Y, Wu X, Cai H, Liu Z, et al.
Int Immunopharmacol
. 2022 Nov;
113(Pt B):109431.
PMID: 36384076
Artemisinins are well-known antimalarial drugs with clinical safety. In addition to antimalarial effects, their anti-inflammatory and immunoregulatory properties have recently attracted much attention in the treatment of inflammatory diseases. However,...
5.
Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation
Chen X, Chen Y, Ou Y, Min W, Liang S, Hua L, et al.
Biochem Pharmacol
. 2022 Nov;
206:115326.
PMID: 36326534
The abnormal activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome plays an important role in the pathogenesis of psoriasis. Accordingly, the inhibition of NLRP3 inflammasome...
6.
Hao Y, Ou Y, Zhang C, Chen H, Yue H, Yang Z, et al.
Brain Res
. 2022 Sep;
1795:148073.
PMID: 36075466
More than 30 % of individuals with epilepsy are refractory to currently available drugs, highlighting the urgent need to develop novel candidate drugs. Accumulating evidence implicates the key role of...
7.
Wu X, Sun P, Chen X, Hua L, Cai H, Liu Z, et al.
J Med Chem
. 2022 Sep;
65(18):11985-12001.
PMID: 36063115
NLRP3 inflammasome activation plays a critical role in inflammation-related disorders. More small-molecule entities are needed to study the mechanism of NLRP3 inflammasome activation and to validate the efficacy and safety...
8.
Chen Y, Chen X, Liang S, Ou Y, Lin G, Hua L, et al.
Chem Biol Interact
. 2022 Aug;
365:110122.
PMID: 36002070
Psoriasis is a common chronic autoinflammatory/autoimmune skin disease associated with elevated pro-inflammatory cytokines. The pivotal role of interleukin (IL)-1β and nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3)...
9.
Liang S, Yang Z, Hua L, Chen Y, Zhou Y, Ou Y, et al.
Eur J Pharmacol
. 2022 Jul;
930:175156.
PMID: 35868446
The maturation and secretion of interleukin-1β (IL-1β) mediated by NLRP3 inflammasome activation plays an important role in the progression of many inflammatory diseases. Inhibition of NLRP3 inflammasome activation may be...
10.
Yue H, Yang Z, Ou Y, Liang S, Deng W, Chen H, et al.
Int Immunopharmacol
. 2021 Jun;
97:107819.
PMID: 34098486
Tanshinones, the active ingredients derived from the roots of Salvia miltiorrhiza, have been widely used as traditional medicinal herbs for treating human diseases. Although tanshinones showed anti-inflammatory effects in many...