Yingnan Lei
Overview
Explore the profile of Yingnan Lei including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
125
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0
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Recent Articles
1.
Lei Y, Duong M, Krivec N, Janssens C, Regin M, Huyghebaert A, et al.
Cell Prolif
. 2025 Feb;
:e13813.
PMID: 39908990
Chromosomal abnormalities acquired during cell culture can compromise the differentiation potential of human pluripotent stem cells (hPSCs). In this work, we identified a diminished differentiation capacity to retinal progenitor cells...
2.
Regin M, Lei Y, Couvreu de Deckersberg E, Janssens C, Huyghebaert A, Guns Y, et al.
Elife
. 2024 Dec;
12.
PMID: 39652462
About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20% in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy new-borns with normal karyotypes. Studies...
3.
Krivec N, Couvreu de Deckersberg E, Lei Y, Al Delbany D, Regin M, Verhulst S, et al.
Cell Death Dis
. 2024 Nov;
15(11):852.
PMID: 39572522
Gain of 1q is a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of...
4.
Al Delbany D, Ghosh M, Krivec N, Huyghebaert A, Regin M, Duong M, et al.
Cells
. 2024 Aug;
13(16).
PMID: 39195283
Human pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study...
5.
Lei Y, Al Delbany D, Krivec N, Regin M, Couvreu de Deckersberg E, Janssens C, et al.
Stem Cell Reports
. 2024 Mar;
19(4):562-578.
PMID: 38552632
Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, because cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent...
6.
Wang D, Yang Y, Lei Y, Tzvetkov N, Liu X, Yeung A, et al.
Pharmacol Rev
. 2019 Sep;
71(4):596-670.
PMID: 31554644
Foam cell formation and further accumulation in the subendothelial space of the vascular wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the atherosclerotic lesions can be...
7.
Peng J, Gao K, Gao T, Lei Y, Han P, Xin H, et al.
Theriogenology
. 2015 Oct;
84(9):1636-43.
PMID: 26435260
Tissue inhibitors of metalloproteinases (TIMPs) are associated with several reproductive processes, such as mammalian follicular growth, ovulation, CL formation, and embryonic development. However, the expression and function of TIMPs in...
8.
Hou J, An X, Song Y, Gao T, Lei Y, Cao B
PLoS One
. 2015 Jul;
10(7):e0133015.
PMID: 26186555
Background: 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism by irreversibly converting 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, a predominant circulating form of folate. Folate is reportedly important for milk protein...
9.
Peng J, Xin H, Han P, Gao K, Gao T, Lei Y, et al.
Mol Cell Endocrinol
. 2015 Jun;
412:104-15.
PMID: 26054746
Tissue inhibitor of metalloproteinase 3 (TIMP3) played a key role in female reproduction. However, its expression and function in goat are still unclear. In the present study, the full-length cDNA...
10.
An X, Hou J, Gao T, Lei Y, Li G, Song Y, et al.
Theriogenology
. 2015 Mar;
83(9):1477-1483.e1.
PMID: 25799469
Single-nucleotide polymorphisms (SNPs) located at microRNA-binding sites (miR-SNPs) can affect the expression of genes. This study aimed to identify the miR-SNPs associated with litter size. Guanzhong (n = 321) and...