Yi-Shyun Lai
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Explore the profile of Yi-Shyun Lai including associated specialties, affiliations and a list of published articles.
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11
Citations
47
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Recent Articles
1.
Hsiao S, Liao W, Chang H, Lai Y, Chan T, Chen Y, et al.
Biochim Biophys Acta Gen Subj
. 2024 Jun;
1868(9):130660.
PMID: 38871061
Caveolin-1 is critical for interacting with the TGF-β receptor (TGFβR) and EGF receptor (EGFR) signaling, often observed in advanced cancers and tissue fibrosis. However, the mechanism underlying caveolin-1-mediated transactivation of...
2.
Lai Y, Hsieh M, Nguyen T, Chen Y, Wang H, Chiu W
Open Biol
. 2024 Apr;
14(4):240001.
PMID: 38653331
Autophagy is a double-edged sword for cells; it can lead to both cell survival and death. Calcium (Ca) signalling plays a crucial role in regulating various cellular behaviours, including cell...
3.
Lai Y, Chan T, Nguyen T, Lin T, Chao Y, Wang C, et al.
FEBS J
. 2023 Dec;
291(5):1027-1042.
PMID: 38050648
The primary cilium is an antenna-like organelle protruding from the cell surface that can detect physical and chemical stimuli in the extracellular space to activate specific signaling pathways and downstream...
4.
Sun C, Lee S, Chen L, Lai C, Shen Z, Chen N, et al.
Cell Signal
. 2023 Jun;
109:110755.
PMID: 37315750
Chronic epithelial defects of the cornea, which are usually associated with severe dry eye disease, diabetes mellitus, chemical injuries or neurotrophic keratitis, as well as aging, are an unmet clinical...
5.
Lai Y, Chang C, Chen Y, Nguyen T, Xu J, Chen Y, et al.
J Cell Sci
. 2023 May;
136(12).
PMID: 37232206
Mitochondrial dynamics regulate the quality and morphology of mitochondria. Calcium (Ca2+) plays an important role in regulating mitochondrial function. Here, we investigated the effects of optogenetically engineered Ca2+ signaling on...
6.
Nguyen T, Lai Y, Chen Y, Lin T, Nguyen N, Chiu W
Cancer Med
. 2023 Feb;
12(8):9723-9737.
PMID: 36757143
Background: Hypoxia is commonly characterized by malignant tumors that promote the aggressiveness and metastatic potential of cancer. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with...
7.
Chao Y, Huang B, Peng I, Lee P, Lai Y, Chiu W, et al.
J Cell Physiol
. 2022 Oct;
237(12):4487-4503.
PMID: 36251015
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of its late diagnosis and chemoresistance. Primary cilia, the cellular antennae, are observed in most human cells to...
8.
Cheng H, Chiu W, Lai Y, Truong T, Lee P, Huang C
Ultrasonics
. 2022 Oct;
127:106852.
PMID: 36201953
Chronic wounds have negative physical and psychological effects on patients and increase the health care burden. Consequently, chronic wound in the elderly population is an important issue. Ultrasound can be...
9.
Truong T, Chiu W, Lai Y, Huang H, Jiang X, Huang C
Ultrasonics
. 2022 Apr;
124:106739.
PMID: 35367809
Motor neuron diseases (MND) including amyotrophic lateral sclerosis and Parkinson disease are commonly neurodegenerative, causing a gradual loss of nerve cells and affecting the mechanisms underlying changes in calcium (Ca)-regulated...
10.
Lai Y, Chang Y, Chen Y, Xu J, Yu C, Chang S, et al.
J Cell Physiol
. 2020 Nov;
236(6):4681-4693.
PMID: 33244795
The ability of a single Ca ion to play an important role in cell biology is highlighted by the need for cells to form Ca signals in the dimensions of...