Yeng-Jeng Shaw
Overview
Explore the profile of Yeng-Jeng Shaw including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
154
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0
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Recent Articles
1.
Zhu J, Huang J, Tseng P, Yang Y, Fowble J, Shiau C, et al.
Cancer Res
. 2019 Apr;
79(7):1716.
PMID: 30936080
No abstract available.
2.
Garrison J, Shaw Y, Chen C, Kyprianou N
Cancer Res
. 2007 Dec;
67(23):11344-52.
PMID: 18056461
Previous evidence showed the ability of the quinazoline-based alpha(1)-adrenoreceptor antagonist doxazosin to suppress prostate tumor growth via apoptosis. In this study, we carried out structural optimization of the chemical nucleus...
3.
Shaw Y, Yang Y, Garrison J, Kyprianou N, Chen C
J Med Chem
. 2004 Aug;
47(18):4453-62.
PMID: 15317457
The alpha1-adrenoreceptor antagonist doxazosin induces apoptosis in malignant cells with moderate potency via an alpha1-adrenoreceptor-independent mechanism. Here, we demonstrate that the ability of doxazosin to induce apoptosis in PC-3 prostate...
4.
Zhu J, Huang J, Tseng P, Yang Y, Fowble J, Shiau C, et al.
Cancer Res
. 2004 Jun;
64(12):4309-18.
PMID: 15205346
The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celecoxib mediates apoptosis. Celecoxib, however, is a weak PDK-1 inhibitor (IC(50), 48...