Yen-Hsi Chen
Overview
Explore the profile of Yen-Hsi Chen including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
557
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Recent Articles
1.
Jaroentomeechai T, Karlsson R, Goerdeler F, Teoh F, Gronset M, de Wit D, et al.
Nat Commun
. 2024 Nov;
15(1):9668.
PMID: 39516489
Access to defined glycans and glycoconjugates is pivotal for discovery, dissection, and harnessing of a range of biological functions orchestrated by cellular glycosylation processes and the glycome. We previously employed...
2.
Vidal-Calvo E, Martin-Salazar A, Choudhary S, Dagil R, Raghavan S, Duvnjak L, et al.
Nat Commun
. 2024 Aug;
15(1):7553.
PMID: 39215044
Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One such embryonic signature tumors express is oncofetal chondroitin...
3.
Li Z, Di Vagno L, Chawla H, Ni Cheallaigh A, Critcher M, Sammon D, et al.
bioRxiv
. 2024 Jul;
PMID: 38979271
Mammalian cells orchestrate signalling through interaction events on their surfaces. Proteoglycans are an intricate part of these interactions, carrying large glycosaminoglycan polysaccharides that recruit signalling molecules. Despite their importance in...
4.
Bagdonaite I, Marinova I, Rudjord-Levann A, Pallesen E, King-Smith S, Karlsson R, et al.
Nat Commun
. 2023 Nov;
14(1):7000.
PMID: 37919266
Viral and host glycans represent an understudied aspect of host-pathogen interactions, despite potential implications for treatment of viral infections. This is due to lack of easily accessible tools for analyzing...
5.
Chen Y, Tian W, Yasuda M, Ye Z, Song M, Mandel U, et al.
Front Bioeng Biotechnol
. 2023 Mar;
11:1128371.
PMID: 36911201
Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously...
6.
Guimond S, Mycroft-West C, Gandhi N, Tree J, Le T, Spalluto C, et al.
ACS Cent Sci
. 2022 Jun;
8(5):527-545.
PMID: 35647275
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic...
7.
Karlsson R, Chopra P, Joshi A, Yang Z, Vakhrushev S, Clausen T, et al.
Sci Adv
. 2021 Dec;
7(52):eabl6026.
PMID: 34936441
Heparan sulfate (HS) polysaccharides are master regulators of diverse biological processes via sulfated motifs that can recruit specific proteins. 3-O-sulfation of HS/heparin is crucial for anticoagulant activity, but despite emerging...
8.
Jorgensen A, Brandum E, Mikkelsen J, Orfin K, Boilesen D, Egerod K, et al.
Cell Mol Life Sci
. 2021 Sep;
78(21-22):6963-6978.
PMID: 34586443
The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show...
9.
Davies S, Mycroft-West C, Pagani I, Hill H, Chen Y, Karlsson R, et al.
Front Pharmacol
. 2021 Aug;
12:660490.
PMID: 34421587
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a...
10.
Schuurs Z, Hammond E, Elli S, Rudd T, Mycroft-West C, Lima M, et al.
Comput Struct Biotechnol J
. 2021 May;
19:2806-2818.
PMID: 33968333
SARS-CoV-2 has rapidly spread throughout the world's population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily...