Yellamraju U Sasidhar
Overview
Explore the profile of Yellamraju U Sasidhar including associated specialties, affiliations and a list of published articles.
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21
Citations
60
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Recent Articles
1.
Badaya A, Sasidhar Y
J Mol Graph Model
. 2021 Dec;
111:108098.
PMID: 34871981
The N-terminal domain (163 residues) of Human thrombopoietin (hTPO) is highly conserved and responsible for the receptor-binding. The crystal structure of free hTPO is not yet available, but the crystal...
2.
Badaya A, Sasidhar Y
Sci Rep
. 2020 Mar;
10(1):5501.
PMID: 32218488
HIV-1 protease is an essential enzyme in the life cycle of the HIV-1 virus. The conformational dynamics of the flap region of the protease is critical for the ligand binding...
3.
Gupta S, Sasidhar Y
J Mol Graph Model
. 2019 Jan;
88:71-80.
PMID: 30660985
The optimization of β-turns has been used as a strategy to increase protein thermal stability. One example is the S48P mutation in Ribonuclease Sa, introduced to optimize a β-turn, which...
4.
Badaya A, Sasidhar Y
Int J Biol Macromol
. 2018 Jul;
118(Pt B):1696-1707.
PMID: 29990556
F11.2.32 is a monoclonal antibody raised against HIV-1 protease and it inhibits protease activity. While the structure of the epitope peptide in complex with the antibody is known, how protease...
5.
Patel S, Sasidhar Y, Chary K
J Phys Chem B
. 2017 Jul;
121(32):7536-7549.
PMID: 28707888
Some peptides and proteins undergo self-aggregation under certain conditions, leading to amyloid fibrils formation, which is related to many disease conditions. It is important to understand such amyloid fibrils formation...
6.
Gupta S, Sasidhar Y
J Phys Chem B
. 2017 Jan;
121(6):1268-1283.
PMID: 28094941
The rate-limiting step for the folding of the helix-turn-helix (HTH) protein, Z34C, involves β-turn region DPNL. This reverse turn has been observed to be part of the transition state in...
7.
Shukla R, Sasidhar Y
Proteins
. 2015 Jun;
83(7):1352-67.
PMID: 26033223
Earlier immunological experiments with a synthetic 36-residue peptide (75-110) from Influenza hemagglutinin have been shown to elicit anti-peptide antibodies (Ab) which could cross-react with the parent protein. In this article,...
8.
Kaur H, Sasidhar Y
J Mol Model
. 2015 Mar;
21(4):88.
PMID: 25773700
Our recent molecular dynamics (MD) simulation of an insertion/duplication mutant 'L20' of bacteriophage T4 lysozyme demonstrated a solvent induced α→β transition in a loosely held duplicate helical region, while α-helical...
9.
Shukla R, Sasidhar Y
Phys Chem Chem Phys
. 2013 Oct;
15(42):18571-83.
PMID: 24085383
Reverse turns play an important role in protein folding, molecular recognition and in eliciting immune response. While sequence determinants of reverse turns are known, not much is known about their...
10.
Shukla R, Kumar N, Sasidhar Y
J Pept Sci
. 2013 Jun;
19(8):516-27.
PMID: 23794524
An important nucleation event during the folding of staphylococcal nuclease involves the formation of a β-hairpin by the sequence (21) DTVKLMYKGQPMTFR(35) . Earlier studies show that the turn sequence 'YKGQP'...