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Yaw L Siow

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Articles 64
Citations 1226
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Recent Articles
1.
Au-Yeung K, Shang Y, Wijerathne C, Madduma Hewage S, Siow Y, O K
Antioxidants (Basel) . 2023 Apr; 12(4). PMID: 37107258
Acute kidney injury (AKI) often impairs the function of other organs leading to distant organ injury. The liver is the major organ that regulates metabolism and lipid homeostasis in the...
2.
Wijerathne C, Au-Yeung K, Siow Y, O K
Antioxidants (Basel) . 2022 Jun; 11(6). PMID: 35739943
Oxidative stress is a major mediator of adverse outcomes in acute kidney injury (AKI). Deficiency of micronutrients, such as folate, is common in AKI. Our previous study reported that AKI...
3.
Madduma Hewage S, Au-Yeung K, Prashar S, Wijerathne C, O K, Siow Y
Antioxidants (Basel) . 2022 Mar; 11(3). PMID: 35326122
Impaired hepatic lipid metabolism is a hallmark of non-alcoholic fatty liver disease (NAFLD), which has no effective treatment option. Recently, Notch signaling has been identified as an important mediator of...
4.
Wijekoon C, Netticadan T, Siow Y, Sabra A, Yu L, Raj P, et al.
Molecules . 2022 Jan; 27(2). PMID: 35056651
Grapes ( L.) are rich in bioactive molecules contributing to health benefits. Consumption of grapes is linked to reduced incidence of cardiovascular diseases. Studies on table grape cultivars are limited...
5.
Raj P, Louis X, Yu L, Siow Y, Suh M, Aukema H, et al.
J Food Biochem . 2021 Aug; 45(10):e13893. PMID: 34459008
Saskatoon berry (SKB) may have the potential to counter reno-cardiac syndrome owing to its antioxidant capacity. Here, we investigated the renal and cardiovascular effects of SKB-enriched diet in a rat...
6.
Yang C, Wijerathne C, Tu G, Woo C, Siow Y, Madduma Hewage S, et al.
Front Immunol . 2021 Jun; 12:678914. PMID: 34149715
Acute or chronic kidney disease can cause micronutrient deficiency. Patients with end-stage renal disease, kidney transplantation or on dialysis have reduced circulating levels of folate, an essential B vitamin. However,...
7.
Madduma Hewage S, Prashar S, O K, Siow Y
Antioxidants (Basel) . 2021 Apr; 10(4). PMID: 33917360
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally and there is a pressing need for effective treatment. Lipotoxicity and oxidative stress are the important mediators...
8.
Wijerathne C, Madduma Hewage S, Siow Y, O K
Biomolecules . 2020 Nov; 10(11). PMID: 33212962
Patients with acute kidney injury (AKI) have an increased risk of cardiovascular disease. The underlying mechanism of AKI-induced heart injury is not well-understood. Hydrogen sulfide (HS), at physiological concentrations, has...
9.
Shang Y, Madduma Hewage S, Wijerathne C, Siow Y, Isaak C, O K
Front Med (Lausanne) . 2020 Jun; 7:201. PMID: 32582723
Ischemia-reperfusion (IR) is a common risk factor that causes acute kidney injury (AKI). AKI is associated with dysfunction of other organs also known as distant organ injury. The liver function...
10.
Madduma Hewage S, Prashar S, Debnath S, O K, Siow Y
Front Med (Lausanne) . 2020 Apr; 7:80. PMID: 32292787
Chronic low-grade inflammation is a major stimulus for progression of chronic kidney disease (CKD) in individuals consuming high-fat diet. Currently, there are limited treatment options for CKD other than controlling...