Yannick Boege
Overview
Explore the profile of Yannick Boege including associated specialties, affiliations and a list of published articles.
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8
Citations
644
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0
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Recent Articles
1.
Clerbaux L, Cordier P, Desboeufs N, Unger K, Leary P, Semere G, et al.
JHEP Rep
. 2023 Sep;
5(10):100838.
PMID: 37663116
Background & Aims: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the...
2.
Muller K, Honcharova-Biletska H, Koppe C, Egger M, Chan L, Schneider A, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(12).
PMID: 33798093
The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver. However, up to...
3.
Healy M, Boege Y, Hodder M, Bohm F, Malehmir M, Scherr A, et al.
Gastroenterology
. 2020 Mar;
159(1):183-199.
PMID: 32179094
Background & Aims: Intestinal epithelial homeostasis depends on a tightly regulated balance between intestinal epithelial cell (IEC) death and proliferation. While the disruption of several IEC death regulating factors result...
4.
Boege Y, Malehmir M, Healy M, Bettermann K, Lorentzen A, Vucur M, et al.
Cancer Cell
. 2017 Sep;
32(3):342-359.e10.
PMID: 28898696
Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and...
5.
Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, et al.
Hepatology
. 2016 Jul;
64(4):1217-31.
PMID: 27396433
Unlabelled: The IκB-Kinase (IKK) complex-consisting of the catalytic subunits, IKKα and IKKβ, as well as the regulatory subunit, NEMO-mediates activation of the nuclear factor κB (NF-κB) pathway, but previous studies...
6.
Wolf M, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, et al.
Cancer Cell
. 2014 Oct;
26(4):549-64.
PMID: 25314080
Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown....
7.
Weber A, Boege Y, Reisinger F, Heikenwalder M
Swiss Med Wkly
. 2011 May;
141:w13197.
PMID: 21557112
Inflammatory responses in the liver--a central constituent of hepatic wound healing--can be self-limited or persistent depending on the aetiology, liver health state, concentration of toxins or pathogens, and the time...
8.
Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, et al.
Cancer Cell
. 2010 May;
17(5):481-96.
PMID: 20478530
The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that conditional ablation of...