Yann Seimbille
Overview
Explore the profile of Yann Seimbille including associated specialties, affiliations and a list of published articles.
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Articles
60
Citations
1070
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Recent Articles
1.
Hooijman E, de Jong J, Ntihabose C, Bruchertseifer F, Morgenstern A, Seimbille Y, et al.
EJNMMI Radiopharm Chem
. 2025 Feb;
10(1):9.
PMID: 39976810
Background: Targeted alpha therapy with Ac-225 showed to be effective in treating metastatic cancers. However, the complex decay chain requires optimized radiolabeling and quality control. This study aims to determine...
2.
Chapeau D, Beekman S, Piet A, Li L, de Ridder C, Stuurman D, et al.
Bioconjug Chem
. 2024 Oct;
35(11):1823-1834.
PMID: 39395152
The main challenges of conventional chemotherapy lie in its lack of selectivity and specificity, leading to significant side effects. Using a small-molecule drug conjugate (SMDC) ensures specific delivery of a...
3.
Gaspar N, Handula M, Stroet M, Marella-Panth K, Haeck J, Kirkland T, et al.
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125775
Multimodality reporter gene imaging combines the sensitivity, resolution and translational potential of two or more signals. The approach has not been widely adopted by the animal imaging community, mainly because...
4.
van der Heide C, Ma H, Hoorens M, Campeiro J, Stuurman D, de Ridder C, et al.
EJNMMI Radiopharm Chem
. 2024 Jul;
9(1):55.
PMID: 39073475
Background: Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics. FAP-targeting radiotracers have demonstrated to...
5.
Chapeau D, Beekman S, Handula M, Murce E, de Ridder C, Stuurman D, et al.
EJNMMI Radiopharm Chem
. 2024 May;
9(1):44.
PMID: 38775990
Background: Integrating radioactive and optical imaging techniques can facilitate the prognosis and surgical guidance for cancer patients. Using a single dual-labeled tracer ensures consistency in both imaging modalities. However, developing...
6.
Murce E, Spaan E, Beekman S, van den Brink L, Handula M, Stuurman D, et al.
Pharmaceuticals (Basel)
. 2023 Aug;
16(8).
PMID: 37630990
Small-molecule drug conjugates (SMDCs) are compounds in which a therapeutic payload is conjugated to a targeting vector, for specific delivery to the tumor site. This promising approach can be translated...
7.
Chapeau D, Koustoulidou S, Handula M, Beekman S, de Ridder C, Stuurman D, et al.
Pharmaceuticals (Basel)
. 2023 Jul;
16(7).
PMID: 37513897
Peptide receptor radionuclide therapy (PRRT) has been applied to the treatment of neuroendocrine tumors (NETs) for over two decades. However, improvement is still needed, and targeted alpha therapy (TAT) with...
8.
Handula M, Beekman S, Konijnenberg M, Stuurman D, de Ridder C, Bruchertseifer F, et al.
EJNMMI Radiopharm Chem
. 2023 Jun;
8(1):13.
PMID: 37389800
Background: The [Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment resistance and disease recurrence. An interesting alternative could be the somatostatin antagonist,...
9.
Murce E, Ahenkorah S, Beekman S, Handula M, Stuurman D, de Ridder C, et al.
Pharmaceuticals (Basel)
. 2023 Jun;
16(6).
PMID: 37375829
Bifunctional chelators (BFCs) are a key element in the design of radiopharmaceuticals. By selecting a BFC that efficiently complexes diagnostic and therapeutic radionuclides, a theranostic pair possessing almost similar biodistribution...
10.
Beaufrez J, Guillouet S, Seimbille Y, Perrio C
Pharmaceuticals (Basel)
. 2023 May;
16(5).
PMID: 37242419
The development of F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications. The hydrophilicity of the...