Yair Gat
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Explore the profile of Yair Gat including associated specialties, affiliations and a list of published articles.
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10
Citations
164
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Recent Articles
1.
Langer L, Bonneau F, Gat Y, Conti E
Elife
. 2021 Oct;
10.
PMID: 34698635
The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is...
2.
Langer L, Gat Y, Bonneau F, Conti E
Elife
. 2020 May;
9.
PMID: 32469312
PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundamental cellular processes. PIKK family member SMG1 orchestrates progression of an RNA quality control pathway, termed...
3.
Gat Y, Schuller J, Lingaraju M, Weyher E, Bonneau F, Strauss M, et al.
Nat Struct Mol Biol
. 2019 Dec;
26(12):1089-1093.
PMID: 31792449
We report the 3.45-Å resolution cryo-EM structure of human SMG1-SMG8-SMG9, a phosphatidylinositol-3-kinase (PI(3)K)-related protein kinase (PIKK) complex central to messenger RNA surveillance. Structural and MS analyses reveal the presence of...
4.
Horowitz B, Javitt G, Ilani T, Gat Y, Morgenstern D, Bard F, et al.
Glycobiology
. 2018 May;
28(8):580-591.
PMID: 29757379
Quiescin sulfhydryl oxidase 1 (QSOX1) catalyzes the formation of disulfide bonds in protein substrates. Unlike other enzymes with related activities, which are commonly found in the endoplasmic reticulum, QSOX1 is...
5.
Moran T, Gat Y, Fass D
FEBS J
. 2015 May;
282(14):2746-57.
PMID: 25962468
Unlabelled: The ~ 800 kDa laminin heterotrimer forms a distinctive cross-shaped structure that further self-assembles into networks within the extracellular matrix. The domains at the laminin chain termini, which engage...
6.
Biran S, Gat Y, Fass D
PLoS One
. 2014 Dec;
9(12):e113431.
PMID: 25437863
The widespread thioredoxin superfamily enzymes typically share the following features: a characteristic α-β fold, the presence of a Cys-X-X-Cys (or Cys-X-X-Ser) redox-active motif, and a proline in the cis configuration...
7.
Gat Y, Vardi-Kilshtain A, Grossman I, Major D, Fass D
Protein Sci
. 2014 Jun;
23(8):1102-12.
PMID: 24888638
Thioredoxin superfamily proteins introduce disulfide bonds into substrates, catalyze the removal of disulfides, and operate in electron relays. These functions rely on one or more dithiol/disulfide exchange reactions. The flavoenzyme...
8.
Salama-Alber O, Gat Y, Lamed R, Shimon L, Bayer E, Frolow F
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2012 Sep;
68(Pt 9):1116-9.
PMID: 22949209
In Ruminococcus flavefaciens, a predominant fibre-degrading bacterium found in ruminants, cellulosomal proteins are anchored to the bacterial cell wall through a relatively small ScaE scaffoldin which includes a single type...
9.
Alon A, Grossman I, Gat Y, Kodali V, DiMaio F, Mehlman T, et al.
Nature
. 2012 Jul;
488(7411):414-8.
PMID: 22801504
Protein stability, assembly, localization and regulation often depend on the formation of disulphide crosslinks between cysteine side chains. Enzymes known as sulphydryl oxidases catalyse de novo disulphide formation and initiate...
10.
Zeytuni N, Ozyamak E, Ben-Harush K, Davidov G, Levin M, Gat Y, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(33):E480-7.
PMID: 21784982
The magnetosome, a biomineralizing organelle within magnetotactic bacteria, allows their navigation along geomagnetic fields. Magnetosomes are membrane-bound compartments containing magnetic nanoparticles and organized into a chain within the cell, the...